lipoic acid

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lipoic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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Lipoic Acid


6,8-epi-dithio-octanoic acid, a widespread naturally occurring coenzyme, related to enzymes of the class of oxidoreductases. It exists in the form of crystals with melting point 59°-60°C and was first isolated from bull’s liver in 1941 (30 mg of lipoic acid was obtained from 10 tons of liver).

Lipoic acid participates in the transfer of acyl groups (acid radicals) and in biological oxidation reactions (for example, oxidative decarboxylation of pyruvic and ketoglutaric acids for conversion into acetyl-CoA and succinyl-CoA, respectively, with liberation of carbon dioxide). The oxidized form of lipoic acid is transformed into a reduced form, which is then reconverted into the oxidized form upon action of a specific enzyme:

Lipoic acid is the growth factor (vitamin) in certain microorganisms; it exists in composite protein form in the cells of plant and animal tissues.

lipoic acid

[lī′pō·ik ′as·əd]
C8H14O2S2 A compound which participates in the enzymatic oxidative decarboxylation of α-keto acids in a stage between thiamine pyrophosphate and coenzyme A.
References in periodicals archive ?
Alleviation of lindane induced toxicity in testis of Swiss mice (Mus musculus) by combined treatment with vitamin C, vitamin E and alpha-lipoic acid.
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Both alpha-lipoic acid and acetyl-L-carnitine are considered safe at the recommended daily doses of 200 mg per day for lipoic acid and 500 mg per day for ALCAR, although you can take lower doses if you want.
Alpha-lipoic acid as a new treatment option for Alzheimer's disease--48 months follow-up analysis.
Juice Organics Vitamins C and E, Topical CoQ10 and Vitamin Antioxidant flax and borage seed, alpha-lipoic acid are Serum CoQ10, white grape potent antioxidants.
The effect of alpha-lipoic acid on the neurovascular reflex are in patients with diabetic neuropathy assessed by capillary microscopy.
Extensive research and clinical experience have indicated that alpha-lipoic acid is safe, well tolerated, and effective in providing symptomatic relief of diabetic neuropathy.
Alexander and colleagues confirmed that alpha-lipoic acid stimulates peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC1-alpha), which is known to control some aspects of how muscles respond to exercise.
Effects of alpha-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss.
Previous studies from our laboratory have shown that addition of alpha-lipoic acid ([alpha]-LA) to diets could enhance the antioxidant capability of broilers (Zhang et al.
Researchers transdermally administered a mixture of antioxidants, alpha-lipoic acid (LA) (0.
Effects of 3-month treatment with the antioxidant alpha-lipoic acid in diabetic peripheral neuropathy," Rom J Intern Med, July-September 1999.