lipoic acid

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lipoic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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Lipoic Acid

 

6,8-epi-dithio-octanoic acid, a widespread naturally occurring coenzyme, related to enzymes of the class of oxidoreductases. It exists in the form of crystals with melting point 59°-60°C and was first isolated from bull’s liver in 1941 (30 mg of lipoic acid was obtained from 10 tons of liver).

Lipoic acid participates in the transfer of acyl groups (acid radicals) and in biological oxidation reactions (for example, oxidative decarboxylation of pyruvic and ketoglutaric acids for conversion into acetyl-CoA and succinyl-CoA, respectively, with liberation of carbon dioxide). The oxidized form of lipoic acid is transformed into a reduced form, which is then reconverted into the oxidized form upon action of a specific enzyme:

Lipoic acid is the growth factor (vitamin) in certain microorganisms; it exists in composite protein form in the cells of plant and animal tissues.

lipoic acid

[lī′pō·ik ′as·əd]
(biochemistry)
C8H14O2S2 A compound which participates in the enzymatic oxidative decarboxylation of α-keto acids in a stage between thiamine pyrophosphate and coenzyme A.
References in periodicals archive ?
Alleviation of lindane induced toxicity in testis of Swiss mice (Mus musculus) by combined treatment with vitamin C, vitamin E and alpha-lipoic acid. Indian J Exp Biol.
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
After the clinical assessment at baseline, each patient was randomly assigned to one of the three double-blind, study arms: 10.000 oxygen radical absorbance capacity units (ORAC) antioxidant diet plus Alpha-lipoic acid (n = 25, group 1), 10.000 ORAC antioxidant diet plus placebo (n = 27, group 2), and controls (n = 19, group 3), with no changes in dietary habits.
In humans, alpha-lipoic acid has been shown to help lower blood pressure, blood sugar, and triglycerides; reverse insulin resistance; and prevent diabetic neuropathy.
Juice Organics Vitamins C and E, Topical CoQ10 and Vitamin Antioxidant flax and borage seed, alpha-lipoic acid are Serum CoQ10, white grape potent antioxidants.
I have found considerable relief taking a supplement called alpha-lipoic acid 250 mg per day.
The free radical scavenger, alpha-lipoic acid, protects against cerebral ischemia-reperfusion injury in gerbils.
When it comes to healthy-aging supplements, the medical evidence comes out strongly in favor of alpha-lipoic acid and acetyl-L-carnitine.
Previous studies from our laboratory have shown that addition of alpha-lipoic acid ([alpha]-LA) to diets could enhance the antioxidant capability of broilers (Zhang et al., 2009; Chen et al., 2011) and piglets (Bai et al., 2012).
Jones, "Evidence for using alpha-lipoic acid in reducing lipoprotein and inflammatory related atherosclerotic risk," Journal of Dietary Supplements, vol.
Researchers transdermally administered a mixture of antioxidants, alpha-lipoic acid (LA) (0.5%) and proanthocyanidin PA(0.3%) in a standard cosmetic vehicle base formulation supplemented with 2% benzyl alcohol as a penetration enhancer, a mixture of essential amino acids (0.2%).
"Effects of 3-month treatment with the antioxidant alpha-lipoic acid in diabetic peripheral neuropathy," Rom J Intern Med, July-September 1999.