melanocyte-stimulating hormone

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melanocyte-stimulating hormone

[mə′lan·ə‚sīt ¦stim·yə‚lād·iŋ ′hȯr‚mōn]
(biochemistry)
A protein substance secreted by the intermediate lobe of the pituitary of humans which causes dispersion of pigment granules in the skin; similar to intermedins in other vertebrates. Abbreviated MSH. Also known as melanophore-dilating principle; melanophore hormone.
References in periodicals archive ?
In the obese rats alpha-MSH was low, despite an abundance of leptin and despite normal levels of gene expression both for its biochemical precursor protein called pro-opiomelanocortin (POMC) and for a key enzyme called PC2 that processes POMC in brain cells.
The researchers showed in laboratory tests alpha-MSH combined with a widely-used polymer produced a material that fights inflammation in dental pulp fibroblasts.
A third hormone, alpha-MSH, turns the shark's lights off.
They also had higher levels of alpha-MSH in the hypothalamus compared to control animals.
MELANOTAN(TM) is EpiTan's brand name for (Nle4,D-Phe7)-alpha-MSH, a synthetic analogue of the naturally occurring hormone alpha-MSH, which stimulates eumelanin production.
Bremelanotide, which is a melanocortin agonist drug candidate, is a synthetic peptide analog of the naturally occurring hormone alpha-MSH (melanocyte-stimulating hormone).

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