tissue plasminogen activator

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tissue plasminogen activator

[¦tish·ü plaz‚min·ə·jən ′ak·tə‚vād·ər]
(medicine)
A proteolytic enzyme that can convert plasminogen to plasmin.
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References in periodicals archive ?
KEY WORDS: Hypernormal shortened DNT, Alteplase, Acute ischemic stroke, Efficacy and safety.
Clinical efficacy and safety of hypernormal shortened door to needle time (DNT) plus individualized low-dose alteplase therapy in treating acute ischemic stroke
It is very important that the attending doctor distinguish the type of stroke, whether ischemic or haemorrhagic, as alteplase will just worsen the stroke if given to those with the haemorrhagic type since this will just promote more bleeding in the brain,' he explained.
Free medicine available for stroke victims-DOH
Deviation from alteplase treatment protocols has been associated with increased mortality (Graham, 2003; Katzan et al.
Time to blood pressure control before thrombolytic therapy in patients with acute ischemic stroke: comparison of labetalol, nicardipine, and hydralazine
But it added that the benefits of using alteplase to treat strokes were "highly time-dependent" and, in a small number of people, there was a risk of haemorrhage.
Clot-busting stroke drug safe, says UK experts
Indicadores relativos ao tratamento de acidente vascular cerebral isquemico antes e depois da instituicao de um protocolo de estabilizacao clinica sem uso de alteplase em cinco hospitais do Sistema Unico de Saude, Distrito Federal, Brasil Variavel 2006/2007 2010/2011 Variacao (%) P (a) Internados (No.
The impact of non-thrombolytic management of acute ischemic stroke in older individuals: the experience of the Federal District, Brazil/Impacto da adocao de medidas inespecificas no tratamento do acidente vascular cerebral isquemico agudo em idosos: a experiencia do Distrito Federal, Brasil
Patients are given alteplase to break down and disperse the clot - a treatment known as thrombolysis.
Safety fears over anti-clotting drug
As a direct result of this work, the Royal Victoria Infirmary in Newcastle changed its policy so that alteplase is routinely used.
National survey reveals real-world impact of university's research; NEWCASTLE UNIVERSITY
Alteplase is a drug for people who have suffered an acute ischaemic stroke - which account for 80 per cent of all strokes.
Vital drug to beat strokes; In Brief
Three trials, the GUSTO (Global Use of Strategies of Open Occluded Coronary Arteries), GISSI-2 (Grupo de Analisis de la Cardiopatia Isquemica Aguda-2), and ISIS (International Study of Infarct Survival-2), compared the effectiveness and safety of streptokinase and alteplase for administration to patients with acute MI.
Circulation savers: thrombolytic therapy
This international trial, led by researchers at the University of Edinburgh, followed patients from 12 different countries - half had the alteplase treatment, which is given intravenously, and half did not.
Stroke drug can improve quality of life among patients
We use an induction dose of 1-10 mg of alteplase to 'lace' the thrombus (depending on the clot burden) and maintain an intra-clot infusion dose of 0.
Acute lower limb ischaemia is a surgical emergency
Comparison of intravenous alteplase with a combined intravenous-endovascular approach in patients with stroke and confirmed arterial occlusion (RECANALISE study): A prospective cohort study.
Emerging role of endovascular and acute ischemic stroke treatments

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