tissue plasminogen activator

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tissue plasminogen activator

[¦tish·ü plaz‚min·ə·jən ′ak·tə‚vād·ər]
(medicine)
A proteolytic enzyme that can convert plasminogen to plasmin.
References in periodicals archive ?
It is very important that the attending doctor distinguish the type of stroke, whether ischemic or haemorrhagic, as alteplase will just worsen the stroke if given to those with the haemorrhagic type since this will just promote more bleeding in the brain,' he explained.
Deviation from alteplase treatment protocols has been associated with increased mortality (Graham, 2003; Katzan et al.
But it added that the benefits of using alteplase to treat strokes were "highly time-dependent" and, in a small number of people, there was a risk of haemorrhage.
Indicadores relativos ao tratamento de acidente vascular cerebral isquemico antes e depois da instituicao de um protocolo de estabilizacao clinica sem uso de alteplase em cinco hospitais do Sistema Unico de Saude, Distrito Federal, Brasil Variavel 2006/2007 2010/2011 Variacao (%) P (a) Internados (No.
Patients are given alteplase to break down and disperse the clot - a treatment known as thrombolysis.
As a direct result of this work, the Royal Victoria Infirmary in Newcastle changed its policy so that alteplase is routinely used.
Alteplase is a drug for people who have suffered an acute ischaemic stroke - which account for 80 per cent of all strokes.
Three trials, the GUSTO (Global Use of Strategies of Open Occluded Coronary Arteries), GISSI-2 (Grupo de Analisis de la Cardiopatia Isquemica Aguda-2), and ISIS (International Study of Infarct Survival-2), compared the effectiveness and safety of streptokinase and alteplase for administration to patients with acute MI.
This international trial, led by researchers at the University of Edinburgh, followed patients from 12 different countries - half had the alteplase treatment, which is given intravenously, and half did not.
We use an induction dose of 1-10 mg of alteplase to 'lace' the thrombus (depending on the clot burden) and maintain an intra-clot infusion dose of 0.
Comparison of intravenous alteplase with a combined intravenous-endovascular approach in patients with stroke and confirmed arterial occlusion (RECANALISE study): A prospective cohort study.