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the presence of characteristics of both sexes in a dioecious organism. These characteristics are not fully developed, that is, they are of intermediate character and are manifested jointly in the same parts of the body. The embryonic development of such an organism, which is called an intersex, begins normally, but from a certain moment it proceeds according to the pattern of the other sexual type. The earlier the organism’s direction of development changes, the more sharply expressed is its intersexuality. Several types of intersexuality are distinguished.

Zygotic, or genetically conditioned, intersexuality is the result of deviation from the norm of the set of sex chromosomes and genes, which are predetermined at the moment of fertilization, when the gametes were combined in the zygote. Depending on the type of disorder, one may distinguish triploid (or aneuploid) intersexuality, which is produced by a deviation from the norm in the number of chromosomes in the zygote, and diploid intersexuality, which is caused by a disruption of the interrelationship of the genes that are brought to the zygote. Triploid (aneuploid) intersexuality was first studied in Drosophila. It was shown that in Drosophila intersexes the interrelationship between the number of sex chromosomes and autosomes is disrupted; the degree of intersexuality of the individual is determined by the chromosome (or gene) balance—that is, by the ratio of the number of sex chromosomes to the number of autosomes (and the sex-determining genes included in them).

The various forms of intersexuality, or so-called pseudohermaphroditism, found in humans are also caused by a disruption of the normal number of sex chromosomes. Depending on which of the chromosomes determining (respectively) the male or female sex are found in excess, one distinguishes “male” or “female” pseudohermaphroditism. Diploid intersexuality is observed in the gypsy moth after the interbreeding of various geographic races. Depending on the type of interbreeding, the intersexuality is noted either in the females or the males. Since in such cases no disruption of the normal number of chromosomes has been discovered, the German biologist R. Goldschmidt put forward the theory in 1912 of the varying “strength” of the genes that determine sex in different races (possibly determined by the qualitative differences in alleles or by the presence of other sex-determining genes).

Hormonal intersexuality is observed in animals, in which the sex glands secrete female or male sex hormones that determine the development of the secondary sex characteristics. When such an animal is castrated and the gonads of the other sex are transplanted to it, a respective masculinization or feminization occurs—that is, the animal becomes an intersex. Similar phenomena are observed in the so-called parasitic castration of crustaceans (found, for example, in the crab Inachus, which is parasitized by the cirripede Sacculina).


Miasoedov, S. V. Iavleniia razmnozheniia i pola v organicheskom mire. Tomsk, 1935.
Ryzhkov, V. L. Genetika pola. Kharkov, 1936.
Liberman, L. L. Vrozhdennye narusheniia polovogo razvitiia. Leningrad, 1966.
Goldschmidt, R. Die sexuellen Zwischenstufen. Berlin, 1931.
Die Intersexualität. Edited by C. Overzier. Stuttgart, 1961.
Ashley, D. J. Human Intersex. Edinburgh-London, 1962.
Teter, I. Gormonalńye narušenija u mužčin i ženščin. Warsaw, 1968;


References in periodicals archive ?
Testicular biopsy is essential for the diagnosis in some patients with ambiguous genitalia, and the evaluation of biopsies of prepubertal testes should involve assessment of the mean tubular diameter and the number of germ cells, Sertoli cells, and Leydig cells (when evaluated) per tubular profile, per unit area, per unit volume, or per testis.
Nonetheless, as medical texts advise, "of all the conditions responsible for ambiguous genitalia, congenital adrenal hyperplasia is the only one that is life-threatening in the newborn period," and even in cases of CAH the "ambiguous" genitalia themselves are not deadly.
Reiner, Abstract, Assignment of Sex in Neonates with Ambiguous Genitalia, in CURRENT OPINIONS ON PEDIATRICS 363-66 (1999).
Born with ambiguous genitalia, Alyx has always felt a little different.
13] Our patient was unaware that he had ambiguous genitalia prior to this presentation with lower urinary tract symptoms and so he had never been counselled about the increased risk of testicular cancer and the need for regular surveillance.
These cases include hemangiomas, vascular anomalies, children with ambiguous genitalia and more.
Also, the test may aid in stratifying the risk of X-linked disorders such as hemophilia, Duchenne muscular dystrophy or cases of ambiguous genitalia, such as congenital adrenal hyperplasia.
Specialists working in various specialties around the world address social and biological determinants in health and disease, with discussion of gender effects on health and healthcare, sex-selective abortion, fetal programming, and ambiguous genitalia.
The finding could help to diagnose cases of ambiguous genitalia.
The finding could help diagnose cases of ambiguous genitalia, New Scientist reported.
In many cases, baby girls with ambiguous genitalia undergo surgery as infants to reposition the clitoris and do necessary vaginal reconstruction.
Intersex is a condition of abnormal sexual maturation resulting in abnormal karyotype or primary or secondary sexual characteristics which can be diagnosed by ambiguous genitalia or abnormal characteristics during adolescent period.