amphotericin B

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amphotericin B

(ăm'fətĕr`ĭsĭn), antibioticantibiotic,
any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics
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 that halts the growth of several disease-causing fungi. Discovered in 1956, it is produced by bacteria of the genus Streptomyces. It is used in lotion or ointment form to treat fungal infections of the skin and is given internally only to patients with potentially fatal fungal infections. Amphotericin B is not effective against bacterial infections.

amphotericin B

[‚am·fə′ter·ə·sən ′bē]
(microbiology)
C46H73O20N The active component of amphotericin, suitable for systemic therapy of deep or superficial mycotic infections.
References in periodicals archive ?
Erroneous determination of hyperphosphatemia ('pseudohyperphosphatemia') in sera of patients that have been treated with liposomal amphotericin B (AmBisome).
Pursuant to the agreement, Mylan will market and distribute in India Gilead's AmBisome (amphotericin B liposome for injection), a treatment for life-threatening, systemic fungal infections, which is also used to treat the parasitic disease visceral leishmaniasis.
Mylan's distribution agreement in India also includes Gilead's AmBisome (amphotericin B liposome for injection) for life-threatening, systemic fungal infections and the parasitic disease visceral leishmaniasis as well as Viread for chronic hepatitis B virus (HBV) infections.
Most of the currently available AmB nanoformulations are lipidbased (Ambisome, Amphocil, and Abelcet) though some are also available in micellar (Fungizone) and nanosuspension form [2].
Food and drug administration approval of AmBisome (liposomal amphotericine B) for treatment of visceral leishmaniasis.
It has been documented in a number of studies that AmBisome is a suitable drug for treatment of PKDL ([26, 28], unpublished data).
For Visceral Leishmania, liposomal amphotericin and Pentostam is suggested but the drug of choice is Ambisome.
In the Indian subcontinent, where VL is endemic, the WHO Leishmaniasis Expert Committee recommends single-dose AmBisome as the safest, most effective treatment for the disease.
At that time, the physician then added amphotericin B (Ambisome), rifampin (Rifadin), azithromycin (Zithromax), and fluconazole (Diflucan) to the medication regimen.
Maes, L., Germonprez, N., Quirijnen, L., Van Puyvelde, L., Cos, P., Vanden Berghe, D., 2004, Comparative activities of the triterpene saponin maesabalide III and liposomal amphotericin B(AmBisome) against Leishmania donovani in hamsters.
AmBisome (liposomal amphotericin B) (product monograph) [electronic version].