Ames test

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Ames test

[′āmz ‚test]
(analytical chemistry)
A bioassay that uses a set of histidine auxotrophic mutants of Salmonella typhimurium for detecting mutagenic and possibly carcinogenic compounds.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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While the statistical evaluation of the results of the Ames test is under discussion (Kim and Margolin, 1999; Mortelmans and Zeiger, 2000) and depends also from the historical data achieved in the individual testing site, the responsible laboratory considered a test item showing a positive response, if the number of revertants was significantly increased (p < 0.05, U-test according to Mann and Whitney, Colquhoun, 1971) (ranges see Table 3) to at least 2-fold of the respective solvent control for TA 98, TA 100 and TA 102 and 3-fold of the solvent control for TA 1535 and TA 1537 in both of the independent experiments.