Karaman, "Analyzing the efficiency in intramolecular amide hydrolysis of Kirby's N-alkylmaleamic acids--a computational approach," Computational and Theoretical Chemistry, vol.
Chin, "Carboxylic acid participation in amide hydrolysis. Evidence that separation of a nonbonded complex can be rate determining," Journal of the American Chemical Society, vol.
Stanley Brown, FCIC, Queen's University: Catalysis Award for his research in electrophilic bromination, amide hydrolysis
mechanisms, catalysis and model enzyme chemistry.
This, however must be followed by amide hydrolysis
and equilibration at the benzylic centre, to give the threo isomer of the ritalinic acid.
* Methods based on the chemical properties of amide groups in PAM, including: (A) fluorescence spectrometry; (B) amide hydrolysis
with ammonia detection, and (C) N-bromination method.
There are two possible ways for these anilines to be formed: through the formation of CDEPA/CMEPA by P450 followed by an arylamidase reaction, or through conjugation of the herbicide with glutathione by displacement of the chlorine atom and subsequent amide hydrolysis
. Li et al.
The loss was apparently due to the amide hydrolysis