Amination


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amination

[‚am·ə′nā·shən]
(organic chemistry)
The preparation of amines.
A process in which the amino group (=NH2) is introduced into organic molecules.

Amination

 

a method of introducting the amino group NH2 into various organic compounds. A typical example of amination is the action of alkali metal amides on heterocyclic bases. Thus, the interaction of pyridine with sodium amide at temperatures of about 200°C leads to the formation of α-aminopyridine (A. E. Chichibabin and O. A. Zeide, 1914):

C5H5N + NaNH2 → C5H4N(NH2) + NaH

Passing benzene vapor with ammonia through an incandescent tube results in a very low output of aniline:

C6H6 + NH3 → C6H5NH2 + H2

References in classic literature ?
The Commission charged with the ex- amination of candidates for posts in the army came with the king to the Valley, whereas they could have transacted their business just as well at home.
Derivatives can be produced using the acid functionality such as saponification, esterification, ethoxylation or amination, while derivatives based on the unsaturation include isomerization, dimerization, epoxidation and hydrogenation acids.
TAs catalyze enantioselective reductive amination reactions of ketones and represent an attractive option for the synthesis of chiral amines, valuable building blocks for the synthesis of several pharmaceutical compounds.
The emphasis of the research is on addressing fundamental challenges such as the use of carbon dioxide (C02) as a synthesis building block or more efficient amination reactions.
Food and Drug Administration (FDA) convened to review one of the first cardiovascular (CV) outcomes trials (CVOT) in patients with Type 2 diabetes, EXAMINE ( EX amination of C A rdiovascular Outco M es: Aloglipt IN vs.
A family of new chiral C2 symmetric amido-oxazolinate ligands, bridged by three different linkers, have been synthesized via a modular Buchwald-Hartwig amination reaction.
Alanine, the [alpha]-amino acid analog of the [alpha]-keto acid pyruvate, is most commonly produced by the reductive amination of pyruvate via alanine transaminase.
Later, pre paration of the Fmoc-protected aza-arginine precursor was accomplished according to Scheme 1A, using reductive amination of 3-([N.
Functionalization of electrospun scaffolds via introduction of chemical functional groups can influence protein adsorption and cell attachment by manipulating the hydrophilicity of the surface [4], Popular processes to functionalize the surface of PCL scaffolds include alkaline hydrolysis [1, 4], amination [3, 5], and immobilization of biomacromolecules such as RGD [6-9], laminin-derived sequences [10], and collagen [3, 11].
Amination the cyanohydrin with ammonia or other amines causes production of alpha-amino-nitriles which are widely used for synthesizing the alpha amino acids.
Included are stereoselective oxidation and reduction methods; stereoselective additions; cyclizations; metatheses and different types of rearrangements; asymmetric transition-metal-catalyzed, organocatalyzed, and biocatalytic reactions; methods for the formation of carbon-heteroatom and heteroatom-heteroatom bonds like asymmetric hydroamination and reduction amination, carboamination and alkylative cyclization, cycloadditions with carbon-heteroatom bond formation, and stereoselective halogenations; and methods for the formation of carbon-sulfur and carbon-phosphorus bonds and asymmetric sulfoxidation.
Firstly, carbon nanotubes were functionalized through five successive stages, including purification, oxidation, amination, melamination and thiolation.