aminoacyl-tRNA synthetase

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aminoacyl-tRNA synthetase

[ə¦mē·nō¦as·əl ¦tē‚är‚en¦ā ′sin·thə‚tās]
(cell and molecular biology)
An enzyme catalyzing the linkage of a transfer ribonucleic acid (tRNA) molecule to its corresponding amino acid during protein synthesis.
References in periodicals archive ?
On the seventh day of hospitalization, the results of analysis of a blood sample taken on the day of admission showed that the patient had positive titers for autoantibodies against aminoacyl tRNA synthetase (ARS), including anti-Jo-1 antibodies.
Of these, the GARS gene located on chromosome 7p produces an aminoacyl tRNA synthetase responsible for charging the associated tRNAs and the first protein of its kind implicated in any inherited human disorder.
One such family of enzymes is the aminoacyl tRNA synthetase, which is responsible for catalyzing the reaction that "charges" transfer-RNA with an amino acid.
In addition to ribosomal proteins, other proteins involved in translation, including peptidases (aminopeptidase C, aminopeptidase N, dipeptidase, peptidase T, proline dipeptidase, prolidase, and Xaa-Pro aminopeptidase), aminoacyl tRNA synthetases (arginyl-tRNA synthetase, isoleucyl-tRNA synthetase, phenylalanyl-tRNA synthetase beta chain, seryltRNA synthetase, threonyl-tRNA synthetase, and tyrosyltRNA synthetase), translation factors (elongation factors G, P, Ts, and Tu, translation initiation factor IF-1, and ribosome recycling factor), and proteins involved in modification (peptidyl-prolyl cis-trans isomerase), were identified in the proteomes from both growth phases.