Comparative analysis of this cellulase with various members of M42 Family of
aminopeptidases indicated the presence of conserved amino acids responsible for the incorporation of metal ions and for the enzymatic activity including His, Asp, Glu, Glu, Asp and His.
Leucine
aminopeptidase activity was zero at hatching (0 DPH) and gradually increased by 3 DPH, then decreased at 5 and 6 DPH.
Sanz-Bravo, "Molecular and pathogenic effects of endoplasmic reticulum
aminopeptidases ERAP1 and ERAP2 in Mhc-I-associated inflammatory disorders: towards a unifying view," Molecular Immunology, vol.
Trichoplusia ni resistance to Cry1Ac toxin in this strain was related to
aminopeptidase N (APN1 and APN6) genes by a trans-regulatory mechanism, where APN1 was down-regulated and APN6 was up-regulated (Zhang et al.
Expression of ENPEP, the gene which encodes
aminopeptidase A, a major Ang II metabolizing enzyme, was expressed at a moderate level in normal lung tissue with a statistically significant (p < 0.001, corrected for multiple comparisons, Table 2) 32% reduction in its expression in lung tumor tissue (Figure S1).
Kain et al., "
Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis," Cancer Research, vol.
Plasmodium berghei: Induction of
aminopeptidase in malaria-resistant strain of Anopheles gambiae.
Genetic characterization of pepP, which encodes an
aminopeptidase P whose deficiency does not affect Lactococcus lactis growth in milk, unlike deficiency of the X-prolyl dipeptidyl
aminopeptidase.
Domain III has a stalk region between residue 40 and residue 70, and after this residue there is a sequence WNXXRLP in APN, which is homologous to non-membrane bound
aminopeptidases (32).
Two enzymes, called
aminopeptidases, have been proposed as being responsible for releasing single amino acids from proteins, or peptides.
Endoplasmic reticulum
aminopeptidases: biology and pathogenic potential.
It is reported that the increase in free amino acids during the post-mortem storage of meat is caused by the action of
aminopeptidases (Migita and Nishimura, 2006).