aminopeptidase

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aminopeptidase

[ə‚mē·nō′pep·tə‚dās]

(biochemistry)

An enzyme which catalyzes the liberation of an amino acid from the end of a peptide having a free amino group.

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CTI BioPharma or the Company) (NASDAQ and MTA: CTIC) today announced that the United Kingdom's National Cancer Research Institute (NCRI) Haematological Oncology Clinical Studies Group has chosen to advance tosedostat, the Company's investigative oral aminopeptidase inhibitor, to the second stage of a randomized clinical trial of low-dose cytarabine plus or minus tosedostat in older patients with Acute Myeloid Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS).

CTI BioPharma Announces United Kingdom National Cancer Research Institute AML Cooperative Group Advances Tosedostat to Next Stage of "Pick-a-Winner" LI-1 Trial for Older Patients with AML or High-Risk MDS

This modification protects it against aminopeptidase degradation, and improves receptor activation and signal transduction in vitro (11).

Industry's First Fluorimetric Assay for Glutaminyl Cyclase

Genetic characterization of pepP, which encodes an aminopeptidase P whose deficiency does not affect Lactococcus lactis growth in milk, unlike deficiency of the X-prolyl dipeptidyl aminopeptidase.

Diversity and technological properties of predominant lactic acid bacteria isolated from Algerian raw goat's milk

Plasmodium berghei: Induction of aminopeptidase in malaria-resistant strain of Anopheles gambiae.

Computation-based virtual screening for designing novel antimalarial drugs by targeting falcipain-III: a structure-based drug designing approach

Purification and characterization of a Cl- activated aminopeptidase from bovine skeletal muscle.

Effect of fermented soybean, "natto" on the production and qualities of chicken meat

The results observed with tosedostat in acute myeloid leukemia add to a growing body of data showing the anti-tumor activity of this aminopeptidase inhibitor and the potential of using this approach to treat blood-related cancers," Alan K.

Tosedostat In Combination With Low Dose Cytarabine Achieves Primary Endpoint In Phase 2 Study In Elderly Patients With AML

Release pattern of aminopeptidase from Biomphalaria glabrata hemocytes subjected to high-level bacterial challenge.

Immunomodulation of Crassostrea gigas and Crassostrea virginica cellular defense mechanisms by Perkinsus marinus

Aminopeptidases (APs) generally are zinc metalloenzymes used in clinical chemistry as markers of disease, and APs also play a physiological role in the regulation of several biologically active peptides (4).

Aminopeptidase activities in breast cancer tissue

CTI) (NASDAQ and MTA: CTIC) today announced the upcoming presentations of data highlighting pacritinib, an oral multikinase inhibitor with dual activity against JAK2 and FLT3, and tosedostat, an oral selective inhibitor of aminopeptidases, at the 56[sup.

CTI BioPharma Announces Data Presentations at the 56th American Society of Hematology Annual Meeting

1992), natural killer cell-like activity (Morsey & De Guise 2003), and apoptosis (Sunila & LaBanca 2003) as well as humoral factors including lysozymes, aminopeptidases, phospholipase C, antimicrobial peptides, and lectins (Mohandas & Cheng 1985, Kamiya et al.

The effects of temperature and salinity on apoptosis of Crassostrea virginica hemocytes and Perkinsus marinus

2) In addition, two or more aminopeptidases may attack the same substrate.

A family with high serum leucine aminopeptidase activity derived from a novel variant CD13

Tosedostat is a first-in-class selective inhibitor of aminopeptidases, which are required by tumor cells to provide amino acids necessary for growth and tumor cell survival.