amodiaquine


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amodiaquine

[‚am·ō′dī·ə‚kwēn]
(pharmacology)
C20H22ClN3O A crystalline compound that melts at 208°C; used as an antimalarial.
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Further, polymorphisms in the pfcrt gene have also been shown to affect parasite susceptibility to chloroquine (22), amodiaquine (23,24), and artemether/ lumefantrine (25).
Currently, treatment for malaria combines rapidly-acting artemisinins with lumefantrine, amodiaquine, mefloquine and other antimalarials for durability.
Antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (CQ) and amodiaquine (AQ), have been used to prevent and treat malaria for many years.
Efficacy of the amodiaquine + sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Cordoba, Colombia, 2006.
There are several antimalarials targeting the blood forms of P vivax, such as chloroquine, amodiaquine, artesunate, artemether, lumefantrine, dihydroartemisinin, piperaquine, chloroquine remains the most widely used as first-line treatment for this species (2,7).
falciparum malaria cases are artemether-lumefantrine (AM-LF), artesunatemefloquine (AS-MQ), artesunate-sulfadoxine-pyrimethamine (AS-SP), dihydroartemisinin-piperaquine, and artesunate amodiaquine (2).
7m treatments of its ArteSunate AmodiaQuine Winthrop (ASAQ Winthrop, which is a fixed dose artemisinin-based combination therapy) is being manufactured with semisynthetic artesunate in Morocco and are being shipped from its distribution centre to Burkina Faso, Burundi, Congo, Liberia, Niger and Nigeria.
In KZN, AL was selected as the preferred ACT as there was no established resistance to the partner drug, lumefantrine, unlike SP or amodiaquine.
Pharmacokinetics of amodiaquine and desethylamodiaquine in pregnant and post-partum women with Plasmodium vivax malaria.
This report is in agreement with other investigators who have reported a prolonged diestrus phase with reduced proestrus and estrus phases following the administration of chloroquine, Garcinia kola, Neem, and amodiaquine (Okanlawon and Ashiru, 1992; Akpantah et al.
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