In addition, LpxK has an N-terminal amphipathic
helix and adjacent basic patch, which likely mediate membrane association; consistent with the presence of these structural elements, LpxK was optimally active at the critical micelle concentration of Triton X-100, and surface dilution of LpxK activity was observed at higher concentrations [70, 71].
Freeman, "ABCA1 and amphipathic
apolipoproteins form high-affinity molecular complexes required for cholesterol efflux," Journal of Lipid Research, vol.
Cholesterol hydrophobically modified pullulan (CHP) is an amphipathic
substance that self-assembles in aqueous solution into nanostructures with a shell of cholesteric hydrophobe and sugar-chain hydrophilicity  (Figure 1).
14-3-3 proteins exist as homo- or heterodimers, in which each 14-3-3 monomer shares a similar helical structure and forms a conserved concave amphipathic
groove that binds to target proteins via specific phosphoserine/phosphothreonine-containing motifs [2-7].
Since the mitochondrial targeting sequence (MTS) of PB1-F2 is an amphipathic
a-helix at the carboxyl terminus , the interaction of PB1-F2 at its N-terminus with HAX-1 would not interfere with its trafficking and translocation to the mitochondria during viral infection.
Chlorhexidine is an amphipathic
molecule that binds to several proteins by a cation-chelating mechanism (Negrelo Newton et al., 2004).
As shown in Figure 1, despite their similar general physical properties, AMPs are classified based on the composition of their amino-acid, size and conformational secondary structures into major groups including peptides with [beta]-strands, amphipathic
a-helices, loop structure, and extended structures.
AmB (fungizone), a polyene antifungal, is an amphipathic
fermentation product of the Gram-positive bacterium, first isolated from Streptomyces nodosus in 1955.
Bacteriocins are in general cationic, amphipathic
molecules as they contain an excess of lysyl and arginyl residues.
In addition to transporting PG, these transporters are also involved in the transport of various molecules, including organic anions, amphipathic
organic compounds, and drugs .
Vitamin E has physiological and biochemical roles including the regulation of protein activation, immunity, gene expression, protection of selenoproteins, preventing free radical damage as an antioxidant scavenger and maintaining the amphipathic
balance of cell membranes (Wang and Quinn, 1999).
Besides, transgenic rice plants against Xanthomonasoryzae and lepidopteran were also generated through the expression of ferredoxin-like amphipathic
(ap1) gene and insecticidal crystal (cry2A*) gene respectively (Tang et al.