ELI-002 is an "AMP KRAS vaccine" containing seven
Amphiphile mKRAS peptides and a proprietary
Amphiphile adjuvant, administered subcutaneously.
In this study, Cu-based
amphiphiles clearly demonstrate superior ability to deliver DNA vaccine in murine experimental models.
Isomaa, "Lipid and protein composition of exovesicles released from human erythrocytes following treatment with
amphiphiles," Biochim Biophys Acta 1190, pp.
The packing symmetry of the solvent spread monolayer of the ion-pair
amphiphiles at the air-water interface depends on the stoichiometry and the magnitude of the charged head groups and the symmetry and the dissymmetry in the precursors' hydrophobic spear (the alkyl chain).
Stupp, "Self-assembly of peptide
amphiphiles: from molecules to nanostructures to biomaterials," Biopolymers, vol.
Increase of the surface pressure, [DELTA][PI], upon the penetration process is attributed to compression of the lipid component owing to the
amphiphile's insertion [46].
Lambeth, "Diradylglycerol synergizes with an anionic
amphiphile to activate superoxide generation and phosphorylation of [p47.sup.phox] in a cell-free system from human neutrophils," Journal of Biological Chemistry, vol.
Park, "Concentration and pH-modulated dual fluorescence in self-assembled nanoparticles of phototautomerizable biopolymeric
amphiphile," Dyes and Pigments, vol.
Taking the
amphiphile SDS as a proxy for ambipolar PU, the polar interaction clearly is much stronger than the nonpolar one, and it is to be expected that t-MWCNTs can be dispersed much better in aqueous PU dispersion as well as in the PU matrix as it develops during curing.
U18666a (3-beta-[2-(diethylamino) ethoxy]androst-5-en-17-one) is a class 2
amphiphile known to inhibit intracellular cholesterol transport and leads to NPC-like free cholesterol accumulation.
Sinou, "Influence of
amphiphile concentration on the enantioselectivity in the rhodium-catalyzed reduction of unsaturated substrates in water," Journal of Molecular Catalysis A, vol.
As a result, these molecules act as lipophilic linkers between the surfactant and the oil molecules, increasing the solubility of the
amphiphile in the non-polar phase (Graciaa et al., 1993).