amphotericin B

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amphotericin B

(ăm'fətĕr`ĭsĭn), antibioticantibiotic,
any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics
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 that halts the growth of several disease-causing fungi. Discovered in 1956, it is produced by bacteria of the genus Streptomyces. It is used in lotion or ointment form to treat fungal infections of the skin and is given internally only to patients with potentially fatal fungal infections. Amphotericin B is not effective against bacterial infections.

amphotericin B

[‚am·fə′ter·ə·sən ′bē]
(microbiology)
C46H73O20N The active component of amphotericin, suitable for systemic therapy of deep or superficial mycotic infections.
References in periodicals archive ?
15 per share, recognized in the third quarter as an impairment charge related to Amphotec product rights.
AMPHOTEC is cleared for marketing in Argentina for treatment of severe systemic and/or deep mycoses in patients for whom conventional amphotericin B therapy cannot be used in effective doses due to toxicity or impaired renal function, or in patients who have failed conventional systemic antifungal therapy.
A total of 149 patients with blood cultures positive for Candida were treated with AMPHOTEC during a course of five clinical trials.
SEQUUS is developing AMPHOTEC for the treatment of life-threatening systemic fungal infections such as aspergillosis, candidiasis and cryptococcal meningitis in patients who have failed other therapy or are intolerant to amphotericin B.
By aligning ourselves with a regional company, we believe that we can accelerate the market acceptance of AMPHOTEC and capitalize on the growing interest in new anti-fungal therapy.
Three Rivers Pharmaceuticals is very pleased to be acquiring Amphotec from InterMune," stated Donald J.
We are pleased that the FDA has agreed to include this additional information in the AMPHOTEC label," said Dr.
Combined revenues from sales of DOXIL and AMPHOTEC were below analysts' expectations.
The increase in cost of goods sold as a percentage of total revenue was primarily the result of a shift in the product mix towards a higher proportion of revenue from Infergen, which has a lower profit margin than Actimmune, and an inventory write-off associated with the divestiture of Amphotec during the quarter.
The results of this study show that AMPHOTEC was significantly more effective than either amphotericin B or Abelcet and that AmBisome was approximately equivalent to AMPHOTEC.