angiopathy

(redirected from Amyloid angiopathy)
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angiopathy

[‚an·je′äp·ə·thē]
(medicine)
Any disease of the vascular system.
References in periodicals archive ?
Cerebral amyloid angiopathy with and without hemorrhage: evidence for different disease phenotypes.
Out of 90 patients of our study 45 cases (50%) were traumatic haemorrhage, 18 cases (20%) were hypertensive haemorrhage, 15 were haemorrhage secondary to aneurysms (16.7%) and 4 cases due to Arteriovenous malformations (4.4%) remaining 8 cases (8.9%) include haemorrhage secondary to amyloid angiopathy (3 cases), haemorrhagic metastasis(1 case) & haemorrhagic Transformation of ischemic infarct (4 cases).
MRI-visible perivascular spaces in cerebral amyloid angiopathy and hypertensive arteriopathy.
EXAMPLE 4, SAMPLE AUTOPSY SIGNOUT: * Frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP), Type A, with: *** Severe temporal lobe atrophy, bilateral *** Frontal lobe atrophy, mild *** Hippocampal sclerosis, bilateral, severe *** Neuronal intranuclear ("lentiform") inclusions * Alzheimer disease neuropathology changes, "high", (A2,B3,C1): *** Thal phase for amyloid plaques: 3 (A2) *** Braak and Braak neurofibrillary stage: V (B3) *** CERAD neuritic plaque score: Predominantly sparse (CI) *** No cerebral amyloid angiopathy is identified * No Lewy body disease pathology is identified Comment: FTLD-TDP, Type A, is identified with associated severe TDP-43 proteinopathy, circumscribed atrophy of bilateral anteromedial temporal lobes and bilateral hippocampal sclerosis.
Soldner et al., "Amyloid-[beta] contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy," Stroke, vol.
In a transgenic mouse model (APPswe/PS1dE9), it was shown that thrombotic cerebrovascular lesions induced a rapid transient increase in amyloid plaque burden and amyloid angiopathy in the area immediately surrounding the infarcted area [59].
A Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of abnormal amyloid protein deposits in the walls of the brain's blood vessels.
FINAL DIAGNOSIS: Cerebral Amyloid Angiopathy with Angiitis
The demographic data, clinical, imagistic (cerebral--CT, cerebral--MRI, EKG), paraclinic data as well as risk factors (hypertension, cerebral amyloid angiopathy, age, aneurysms and vascular malformations, anticoagulant and thrombolytic treatment, hypocholesterolemia, diabetes, heavy alcohol and tobacco use, heritability), treatment, kinetotherapy were all considered.
In amyloid angiopathy there is deposition of amyloid- [beta] in the capillary wall, which also results in microaneurysm formation, concentric splitting, chronic inflammatory infiltrates and fibrinoid necrosis.
Urmoneit, "Apolipoprotein E, smooth muscle cells and the pathogenesis of cerebral amyloid angiopathy: the potential pole of impaired cerebrovascular A[beta] clearance," Annals of the New York Academy of Sciences, vol.
The hurdles for development of an active/passive vaccine are high with side effects (such as vasculitis, encephalopathies, and increased cerebral amyloid angiopathy) or more-practical concerns (such as a high burden for delivery by frequent visits to the clinic and costs) being some of the concerns around this technology.