Also found in: Dictionary, Thesaurus, Medical, Financial, Wikipedia.
Related to Amyloidosis: familial amyloidosis


Deposition of amyloid in one or more organs of the body.



or amyloid dystrophy, a disorder of protein metabolism accompanied by the formation within tissues of a specific protein polysaccharide complex known as amyloid. The progress of the disease is associated with distortion of the protein-synthesizing function of the reticuloendothelial system and with accumulation of anomalous proteins in the blood plasma which act as autoantigens and also stimulate the formation of autoantibodies. As a result of antigen-antibody interaction, there is deposition of widely dispersed proteins which figure in the formation of amyloid. Once deposited in tissues, such as vascular and gland walls, the amyloid displaces functionally specialized elements of the organ; this process leads to the destruction of the organ.

Several types of amyloidosis are recognized: primary, secondary, and senile amyloidosis; amyloidosis with multiple myeloma; and localized tumorlike amyloidosis. Primary amyloidosis has no connection with any other disease; it affects mainly the cardiovascular system, alimentary tract, muscles, and skin. Secondary amyloidosis develops subsequent to other diseases which are accompanied by prolonged suppuration and tissue breakdown, such as tuberculosis, syphilis, and rheumatoid arthritis. It most often affects the spleen, liver, kidneys, adrenal glands, and intestines. Senile amyloidosis usually involves the heart. Amyloidosis may be either general or localized. Im-munodepressive and hepatic preparations are used in its treatment.


References in periodicals archive ?
Rx] in approximately 500 TTR amyloid cardiomyopathy patients diagnosed with either FAC or wt-TTR amyloidosis.
Dialysis-related amyloidosis most often occurs in patients with kidney failure, especially adults older than 60, who have been on hemodialysis for more than five years.
Localized disease is present in about 10% to 20% and most amyloidosis is systemic.
Amyloidosis is a disease process in which proteinaceous material is formed and deposited in soft tissues and organs in response to various cell dyscrasias or inflammatory conditions.
Furthermore, the subtypes of amyloidosis have markedly different clinical implications.
Patient 2 was a 58-year-old white woman, who was first diagnosed with amyloidosis in the liver on a biopsy performed in December 2005.
As a nurse I had heard of myeloma but had never heard of AL Amyloidosis until David was diagnosed with a low grade myeloma and an aggressive form of AL amyloid.
Amyloidosis is an uncommon, progressive disease characterized by extracellular deposition of insoluble fibrillar proteins in tissues leading to organ failure.
Ixazomib is a breakthrough drug showing activity and organ improvement in most of these heavily pretreated AL amyloidosis patients, said Professor Giampaolo Merlini, Director, Center for Research and Treatment of Systemic Amyloidosis, University of Pavia, Italy.
Secondary amyloidosis is a process which can result from various chronic inflammatory reactions, which leads to amyloid deposits in several tissues.