Amyloidosis


Also found in: Dictionary, Thesaurus, Medical, Financial, Wikipedia.
Related to Amyloidosis: familial amyloidosis

amyloidosis

[‚am·ə·loi′dō·səs]
(medicine)
Deposition of amyloid in one or more organs of the body.

Amyloidosis

 

or amyloid dystrophy, a disorder of protein metabolism accompanied by the formation within tissues of a specific protein polysaccharide complex known as amyloid. The progress of the disease is associated with distortion of the protein-synthesizing function of the reticuloendothelial system and with accumulation of anomalous proteins in the blood plasma which act as autoantigens and also stimulate the formation of autoantibodies. As a result of antigen-antibody interaction, there is deposition of widely dispersed proteins which figure in the formation of amyloid. Once deposited in tissues, such as vascular and gland walls, the amyloid displaces functionally specialized elements of the organ; this process leads to the destruction of the organ.

Several types of amyloidosis are recognized: primary, secondary, and senile amyloidosis; amyloidosis with multiple myeloma; and localized tumorlike amyloidosis. Primary amyloidosis has no connection with any other disease; it affects mainly the cardiovascular system, alimentary tract, muscles, and skin. Secondary amyloidosis develops subsequent to other diseases which are accompanied by prolonged suppuration and tissue breakdown, such as tuberculosis, syphilis, and rheumatoid arthritis. It most often affects the spleen, liver, kidneys, adrenal glands, and intestines. Senile amyloidosis usually involves the heart. Amyloidosis may be either general or localized. Im-munodepressive and hepatic preparations are used in its treatment.

V. V. SEROV

References in periodicals archive ?
Long-Term Efficacy and Safety of Inotersen for Hereditary Transthyretin Amyloidosis: NEURO-TTR Open-Label Extension 2-Year by Dr.
With hATTR Compass and the help of our familys physician, we were able to test 27 family members for the genetic variants that cause hATTR amyloidosis in one day, said Angel Male, an hATTR Compass participant and family caregiver.
Similarly, in 2017, about 47 million American were in one of the preclinical AD states: 22 million with amyloidosis, 8.3 million with neurodegeneration, and 16.2 million with both.
AL amyloidosis is a rare systemic disorder caused by an abnormality of plasma cells in the bone marrow.
Amyloidosis is characterized by extracellular accumulation of amorphous fibrillar protein.
The University Hospital of Heidelberg serves as a referral center for autoinflammatory diseases and amyloidosis. FMF diagnosis was established according the Tel Hashomer criteria (22).
While common conditions are more likely to result in hoarseness and dysphagia, amyloidosis is a rare but possible diagnosis.
Localized amyloidosis of the urinary tract is of clinical importance because it mimics urothelial carcinoma.
The company said ONPATTRO is the first-of-its kind RNA interference (RNAi) therapeutic approved by the US Food and Drug Administration (FDA) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.
David Adams, M.D., Ph.D., from the Université Paris-Sud, and colleagues conducted a phase 3 trial involving patients with hereditary transthyretin amyloidosis with polyneuropathy receiving either patisiran (148 patients) or placebo (77 patients).