In pursuit of our second major aim, we will focus on understanding how an anchoring protein
regulates the activity of the calcium-sensitive enzyme that depresses synaptic strength.
An ABc mutant NMDAR would be expected to mimic overexpression of GluN2A at immature synapses, due to the non-specificity of the predominating PSD anchoring protein
, SAP102, for GluN2A or G1uN2B.
At telophase stage, PP1 (a Ser/Thr phosphatase) is targeted to lamin B by A-kinase anchoring protein
(AKAP149) which is a membrane bound PP1 binding protein (Fig.2(c)).
Tyrosine phosphorylation of the A kinase anchoring protein
3 (AKAP3) and soluble adenylate cyclase are involved in the increase of human sperm motility by bicarbonate.
They discuss structural characterization of EPAC by x-ray crystallography; sensory neuron cAMP signaling in chronic pain; monitoring real-time cyclic nucleotide dynamics in subcellular microdomains; identifying complexes of adenylyl with A-kinase anchoring proteins
; assessing cyclic nucleotide binding domain allostery and dynamics by nuclear magnetic resonance spectroscopy; a protocol for expression and purification of cyclic nucleotide-free protein in E.