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Deposition of amyloid in one or more organs of the body.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



or amyloid dystrophy, a disorder of protein metabolism accompanied by the formation within tissues of a specific protein polysaccharide complex known as amyloid. The progress of the disease is associated with distortion of the protein-synthesizing function of the reticuloendothelial system and with accumulation of anomalous proteins in the blood plasma which act as autoantigens and also stimulate the formation of autoantibodies. As a result of antigen-antibody interaction, there is deposition of widely dispersed proteins which figure in the formation of amyloid. Once deposited in tissues, such as vascular and gland walls, the amyloid displaces functionally specialized elements of the organ; this process leads to the destruction of the organ.

Several types of amyloidosis are recognized: primary, secondary, and senile amyloidosis; amyloidosis with multiple myeloma; and localized tumorlike amyloidosis. Primary amyloidosis has no connection with any other disease; it affects mainly the cardiovascular system, alimentary tract, muscles, and skin. Secondary amyloidosis develops subsequent to other diseases which are accompanied by prolonged suppuration and tissue breakdown, such as tuberculosis, syphilis, and rheumatoid arthritis. It most often affects the spleen, liver, kidneys, adrenal glands, and intestines. Senile amyloidosis usually involves the heart. Amyloidosis may be either general or localized. Im-munodepressive and hepatic preparations are used in its treatment.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
While oestrogen deficiency leads to vaginal dryness, dyspareunia and vulvo vaginal burning, androgen deficiency is linked with decreased lipid, fatigue, lack of sexual motivation, and mood changes.
For which the prevalence of androgen deficiency was taken as 12.3%, estimated from Massachusetts Male Aging Study.9 We did not include smokers as variations in testosterone levels were have been reported in smokers.10 In addition subjects suffering from any acute, chronic and systemic illnesses, taking any testosterone supplementation, suffering from hypogonadism and those who indulged in regular exercise11 were also not included in the study.
The Hormone Foundation's patient guide to testosterone therapy in adult men with androgen deficiency syndromes.
Because symptoms like flagging desire and general malaise have a variety of causes, androgen deficiency, like hyperandrogenism, often goes undiagnosed.
The researchers concluded that androgen deficiency accounted for decreases in lean mass, muscle size, and strength.
Relative androgen deficiency in relation to obesity and metabolic status in older men.
Opioid-related androgen deficiency has been documented in one fashion or another since the 1970s, and appears to come on quickly, within days or weeks of starting chronic opioid therapy, she said.
Elderly men have a relative deficiency of testosterone compared with younger men (i.e., partial androgen deficiency of the aged male (PADAM)).
In 2004, as Pfizer terminated its trials of Viagra with women, conceding that they had produced little evidence that it was an effective drug for the treatment of female sexual arousal disorder, another pharmaceutical giant was ramping up its campaign to have androgen deficiency recognized as at the root of women's desire disorders.
ANDROGEN deficiency can make a man vulnerable to many medical problems other than sexual disorders.
(21) These men may develop the symptoms of androgen deficiency despite their testosterone levels dropping due the antagonistic impact of estrogens on testosterone.

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