aneuploidy

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aneuploidy

[′a·nyü‚plȯid·ē]
(genetics)
Deviation from a normal haploid, diploid, or polyploid chromosome complement by the presence in excess of, or in defect of, one or more individual chromosomes.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
As aneuploid cells divide, their genomes become increasingly disorganized to the point where most stop dividing and die.
An increased level of Aurora-B in normal cells has been shown to induce premature chromosome separation and segregation errors, to promote generation of tetraploid and aneuploid cells, which develop a transformed phenotype in vitro and in vivo, and, as above mentioned, to potentiate Ras oncogenic activity [47, 50, 63-65].
"Even though cancer can arise from a set of precise mutations, the majority of malignant tumors possess aneuploid cells, and the reason for this is still an open question," said Di Carlo, who is also a member of the California NanoSystems Institute at UCLA.
Show several karyotypes of normal and aneuploid cells, including the trisomies 21, 18, and 13, and 47 XXY and 45 XO.
These particulate chromate-induced aneuploid cells were able to survive and form colonies (47,48).