ACE inhibitor

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Related to Angiotensin II receptor antagonist: ACE inhibitor, calcium channel blocker

ACE inhibitor

ACE inhibitor (āˌsēˌēˈ, ās) or angiotensin-converting enzyme inhibitor (ănˌjēōtĕnˈsĭn), drug used to reduce elevated blood pressure (see hypertension), to treat congestive heart failure, and to alleviate strain on hearts damaged as a result of a heart attack (see infarction). ACE inhibitors block production of an enzyme that helps convert the protein angiotensin 1 into angiotensin 2, a protein that makes blood vessels constrict and promotes retention of fluid, raising blood pressure. Thus ACE inhibitors act to widen the blood vessels and make it easier for the heart to pump blood through the body. captopril (Capoten), ramipril (Altace), and enalapril (Vasotec) are commonly used ACE inhibitors. Angiotensin-receptor blockers (ARBs), such as losartan (Cozaar) and valsartan (Diovan), reduce hypertension by displacing angiotensin 2 from receptors on the surface of cells. ARBs are used as alternatives to the less expensive ACE inhibitors because they have fewer side effects.
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References in periodicals archive ?
Kohli, "QSAR studies on substituted benzimidazoles as angiotensin II receptor antagonists: kNN-MFA approach," Arabian Journal of Chemistry, 2011.
Bristol-Myers Squibb's pharmaceutical research institute will head the development effort for the angiotensin II receptor antagonist.
The FOCUS study, a randomized, double-blind, parallel-group, placebo controlled study, evaluated the efficacy of two dosing regimens of fremanezumab in a large population of adult patients with episodic or chronic migraine who had documented prior inadequate response within the past ten years to two-to-four pharmacological classes of migraine preventive medications: beta blockers, anticonvulsants, tricyclic antidepressants, calcium channel blockers, angiotensin II receptor antagonists, onabotulinumtoxinA, or valproic acid.
In addition, angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARAs), and endothelin receptor antagonists (ERAs) have been used for antihypertensive therapy over the past 20 years [12,13].
Irbesartan is an effective antihypertensive agent belonging to the category of angiotensin II receptor antagonists. Liver injury has been reported with irbesartan and other members of this group.
Neuroprotective effects of antihypertensive medication are achieved by angiotensin-converting enzyme inhibitors and diuretics, according to some authors (3), but also by angiotensin II receptor antagonists and dihydropiridines, according to other authors (4).

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