ACE inhibitor

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ACE inhibitor

(ā'sē'ē`, ās) or

angiotensin-converting enzyme inhibitor

(ăn'jēōtĕn`sĭn), drug used to reduce elevated blood pressure (see hypertensionhypertension
or high blood pressure,
elevated blood pressure resulting from an increase in the amount of blood pumped by the heart or from increased resistance to the flow of blood through the small arterial blood vessels (arterioles).
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), to treat congestive heart failurecongestive heart failure,
inability of the heart to expel sufficient blood to keep pace with the metabolic demands of the body. In the healthy individual the heart can tolerate large increases of workload for a considerable length of time.
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, and to alleviate strain on hearts damaged as a result of a heart attack (see infarctioninfarction,
blockage of blood circulation to a localized area or organ of the body resulting in tissue death. Infarctions commonly occur in the spleen, kidney, lungs, brain, and heart.
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). ACE inhibitors block production of an enzyme that helps convert the protein angiotensin 1 into angiotensin 2, a protein that makes blood vessels constrict and promotes retention of fluid, raising blood pressure. Thus ACE inhibitors act to widen the blood vessels and make it easier for the heart to pump blood through the body. captopril (Capoten), ramipril (Altace), and enalapril (Vasotec) are commonly used ACE inhibitors. Angiotensin-receptor blockers (ARBs), such as losartan (Cozaar) and valsartan (Diovan), reduce hypertension by displacing angiotensin 2 from receptors on the surface of cells. ARBs are used as alternatives to the less expensive ACE inhibitors because they have fewer side effects.
References in periodicals archive ?
The effects of chronic usage of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on contrast-induced nephropathy in low-risk patients," Anadolu Kardiyoloji Dergisi, vol.
Heart failure treatment with angiotensin-converting enzyme inhibitors in hospitalized Medicare patients in 10 states.
Angiotensin-converting enzyme inhibitors in the management of cardiac failure: are we ignoring the evidence?
Pregnancy outcome based on timing of exposure to angiotensin-converting enzyme inhibitors (ACEIs), by week of last exposure(*)--United States, Canada, and Israel, 1987-1995
As such, it would be prescribed only if symptoms persisted after the use of such drugs as angiotensin-converting enzyme inhibitors and beta blockers, which reduce the risk of hospitalization and death.
In addition to the AIIRAs, these drug classes include angiotensin-converting enzyme inhibitors (ACEIs), calcium-channel blockers (CCBs) and diuretics.
In a large national insurance database, the researchers collected records of over 10,000 patients discharged between 2006 and 2011 after hospitalizations for heart attacks who initiated treatment with generic beta-blockers, angiotensin-converting enzyme inhibitors, angiotensin-II-receptor blockers, or cholesterol-lowering statins.
The patient was prescribed by angiotensin-converting enzyme inhibitors, beta-blockers, warfarin, statins and diuretics.
These drugs are often overprescribed, as a result of aggressive marketing and in the absence of evidence that they are better than angiotensin-converting enzyme inhibitors.
Drugs that prevent ischemic events, or lessen their impact, such as anticoagulants, statins, angiotensin-converting enzyme inhibitors, and aldosteron antagonists, all reduce the incidence of sudden death.
SEATTLE -- Angiotensin-converting enzyme inhibitors that cross the bloodbrain barrier slow mental decline by about 50% relative to the decline seen in patients on other antihypertensives, according to an observational study of 1,074 hypertensive subjects followed for a median of 6 years.

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