In breast cancer or prostate cancer, Notchseems to act as an oncogene,[sup] while in bladder cancer it possesses characteristics as a tumor suppressor gene.[sup] Moreover, it may act as both oncogene and tumor suppressor gene in prostate cancer simultaneously.[sup] An important role for Notch signaling in thyroid cancer has been well documented and the members of Notch signaling are abnormally expressed in thyroid cancer.[sup], NRARP encodes a small evolutionarily conserved protein containing two ankyrin repeats which is a component of a negative feedback system to attenuate Notch pathway-mediated signaling.
Background: The Notch-regulated ankyrin repeat protein (NRARP) is recently found to promote proliferation of breast cancer cells.
inhibitor of NF- B binds NF-B through specific ankyrin repeats
of the C-terminus.
The first, the potential phosphorylated domain, located between the ankyrin repeats
and the proline, glutamic acid, serine, and threonine-rich domain, can enhance binding of the NICD to RBP-J[kappa].
There are indications that mechanisms underpinning host-microbe interactions are encoded on the genome of "Candidatus Poribacteria WGA A3." These are proteins with eukaryote-like domains, such as ankyrin repeats and tetratricopeptide repeats (TPR), which are likely to mediate protein-protein interactions (Siegl et al., 2011).
Functional diversity of ankyrin repeats in microbial proteins.
The intracellular domain contains six ankyrin repeats
, the final motif found in Notch.
The center has discovered that B cell scaffold protein with ankyrin repeats
(BANK), a kind of adapter molecule, inhibits the immune response of the B cell.
This gene encodes a 153-160 kDa protein with at least 11 N-terminal ankyrin repeats
and a C-terminus with several tandem repeats but no homology with other proteins.