ankyrin

(redirected from Ankyrin repeats)
Also found in: Medical.

ankyrin

[aŋ′kī·rən]
(cell and molecular biology)
A protein found in the cell membrane of erythrocytes that attaches the membrane to the cytoskeleton protein spectrin.
References in periodicals archive ?
In breast cancer or prostate cancer, Notchseems to act as an oncogene,[sup][15] while in bladder cancer it possesses characteristics as a tumor suppressor gene.[sup][16] Moreover, it may act as both oncogene and tumor suppressor gene in prostate cancer simultaneously.[sup][17] An important role for Notch signaling in thyroid cancer has been well documented and the members of Notch signaling are abnormally expressed in thyroid cancer.[sup][18],[19] NRARP encodes a small evolutionarily conserved protein containing two ankyrin repeats which is a component of a negative feedback system to attenuate Notch pathway-mediated signaling.
Background: The Notch-regulated ankyrin repeat protein (NRARP) is recently found to promote proliferation of breast cancer cells.
The first, the potential phosphorylated domain, located between the ankyrin repeats and the proline, glutamic acid, serine, and threonine-rich domain, can enhance binding of the NICD to RBP-J[kappa].
There are indications that mechanisms underpinning host-microbe interactions are encoded on the genome of "Candidatus Poribacteria WGA A3." These are proteins with eukaryote-like domains, such as ankyrin repeats and tetratricopeptide repeats (TPR), which are likely to mediate protein-protein interactions (Siegl et al., 2011).
Functional diversity of ankyrin repeats in microbial proteins.
The intracellular domain contains six ankyrin repeats, the final motif found in Notch.
The center has discovered that B cell scaffold protein with ankyrin repeats (BANK), a kind of adapter molecule, inhibits the immune response of the B cell.
This gene encodes a 153-160 kDa protein with at least 11 N-terminal ankyrin repeats and a C-terminus with several tandem repeats but no homology with other proteins.