Antabuse


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Antabuse

(ăn`təbyo͞os), trade name for the drug tetraethylthiuram disulfide, used in the treatment of alcoholismalcoholism,
disease characterized by impaired control over the consumption of alcoholic beverages. Alcoholism is a serious problem worldwide; in the United States the wide availability of alcoholic beverages makes alcohol the most accessible drug, and alcoholism is the most
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. Also called sulfiram, Antabuse is nontoxic, but it alters the metabolism of alcohol in the body, making it impossible for one who is taking the drug to drink without experiencing severe discomfort. When alcohol is present the drug increases the concentration of acetaldehyde in the body, causing symptoms resembling those of a bad hangover: the individual feels hot, the face becomes flushed, the neck and head throb, and nausea, vomiting, and headache may follow. Small quantities of alcohol, such as from food sauces and cough medicines, and even inhaled traces from shaving lotions and varnishes, may induce the same symptoms. The drug Temposil, or citrated calcium carbamide, has the same function as Antabuse, but is weaker and safer. The therapeutic use of Antabuse was discovered in the 1930s when workers exposed to tetraethylthiuram disulfide, a chemical used in the rubber industry, became ill after drinking alcoholic beverages.
References in periodicals archive ?
[8.] Kragh H, From Disulfiram to Antabuse: The Invention of a Drug.
Doctors wrote 95,000 prescriptions for withdrawal drugs and 55,500 for Antabuse, which makes people sick when they drink.
There is another called Antabuse or Disulfiram, which makes you violently sick if you drink.
Disulfiram (Antabuse) is a dithiocarbamate (DC) used as an adjunct in the treatment of chronic alcoholism.
The enzyme is blocked by the drug disulfiram - also known as Antabuse - which is sometimes used to help alcoholics quit the habit.
(ii) Her approach is now quite different from anything demonstrated over the last ten years due to motivation enhanced by the pregnancy and birth of a healthy baby, daily Antabuse adjunctive therapy and the attention of social services in monitoring the childcare situation.
Kev took the drug Antabuse to tackle his problem: "Antabuse gives you a bad reaction if alcohol enters your system, and there were times when I did suffer.
I must clear up one thing--I didn't drink on top of antabuse knowingly.
Treatment involved giving alcoholics a drug that would make them vomit if they drank, such as Antabuse, and then force them to drink until they got sick.
Andrew is now on Antabuse - the same drug George Best uses for his alcoholism - and has been teetotal for eight months.
The Providence Summit was sponsored through an educational grant from primary sponsor Odyssey Pharmaceuticals, manufacturer of Antabuse, a federally approved medication to treat alcoholism.