For the caudate nucleus (CN) connectivity, the seed region of interest was placed on the CN, which is isolated by the adjacent structures (medial boundary: the lateral ventricle; lateral boundary: the anterior limb of the internal capsule
Fractional anisotropy and radial diffusivity: diffusion measures of white matter abnormalities in the anterior limb of the internal capsule
Kohl's meta-analysis of 25 published DBS studies, electrode placement in four different DBS target structures produced similar results: the nucleus accumbens, the anterior limb of the internal capsule
, the ventral striatum, and the sub-thalamic nucleus.
There does not appear to be a significant therapeutic difference between stimulation of the thalamus or globus pallidus although stimulation of the anterior limb of the internal capsule
and nucleus accumbens seems to be less effective (25%–50%) for treating TS.