Effects of anterior nucleus
of the thalamus-deep brain stimulation on the neuronal survival in the CA3 region of hippocampus
Zhang, "Stimulation of the anterior nucleus
of the thalamus induces changes in amino acids in the hippocampi of epileptic rats," Brain Research, vol.
[sup],,,,, In this scenario, the main targeted brain regions for DBS include the anterior nucleus
of thalamus (ANT), [sup] the entorhinal cortex (EC) [sup] and the fornix (FX), [sup] which are all parts of so-called Papez memory circuit.
Chianget al., "Deep brain stimulation of the anterior nucleus
of the thalamus: effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus," Epilepsy Research, vol.
Early uncontrolled studies of this application had small patient numbers, but their success led to the Stimulation of the Anterior Nucleus
of the Thalamus for Epilepsy trial of 110 patients with medically refractory partial-onset seizures.
In Medtronic Inc.'s Stimulation of the Anterior Nucleus
of the Thalamus for Epilepsy (SANTE) trial, about 150 adult patients with medically refractory partial-onset epilepsy will receive the Intercept Epilepsy Control System.