Anthelmintic

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Related to Anthelmintic drug: Antihelminthic Drugs

anthelmintic

[¦an·thel¦min·tik]
(pharmacology)
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Anthelmintic

 

(also vermifuge, helminthagogue), a preparation used to treat worm diseases, or helminthiases. The action of different anthelmintics varies. Some preparations, such as Heptylresorcine and Phenasal, damage the cuticle (integument) of helminths, while other preparations, such as santonin, ditrazin, piperazine, and naphtammone, alter the tone and mobility of parasites. Anthelmintics expel helminths from the patient’s body and are used when helminths infest the intestine and its communicating organs (liver, pancreas). Anthelmintics are also used to kill helminths.

Piperazine acts on the neuromuscular system of ascarids, which are subsequently excreted with feces. Phenasal destroys the integument of various tapeworms, including beef tapeworms, dwarf tapeworms, and broad tapeworms. They are then digested in the intestine and their residue is excreted. Chloxyl kills Siberian liver fluke in the liver and pancreas. The parasite is then eliminated into the intestine. Other anthelmintics, such as ditrazin and antimony preparations, destroy helminths, such as filiariae and schistosomes, in the blood, lymphatics, and tissues. Some antihelmintics, such as ditrazin and Chloxyl, are produced chemically. Others are obtained from plants, for example, from Artemisia cina or the extract of male fern.

REFERENCE

Krotov, A. I. Osnovy eksperimental’noi terapii gel’mintozov. Moscow, 1973.

N. N. PLOTNIKOV

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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*: farmers used dewormers but could not recall their identities, f: Vermexin belongs to the Benzimidazole class of anthelmintic drugs. TABLE 5: Effect of disease control practices on parasite prevalence (%) and load (mean epg/opg) in pigs in Bamboutos, Cameroon.
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Even though it was not possible to collect information regarding particular group of anthelmintic drugs however, it was noted that regular deworming was necessary to control infection.
The results from only a few controlled trials of anthelmintic drugs for systemic toxocariasis have been published.
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After adjusting the regression models for sex, age group, temporal pattern, and spatial distribution, we found that exposure to antimycobacterial drugs (odds ratio [OR] 1.09; 95% CrI 1.02-1.16) and anthelmintic drugs (OR 1.07; 95% CrI 1.01-1.13) were associated with increased odds of CA-CDI.
The treatment of haemonchosis is based upon anthelmintic drugs (McKellar and Jackson, 2004), but the worms seem to have developed resistance against these drugs (Mortensen et al., 2003; Kaplan, 2004).
We endorse WHO recommendations to the effect that, 'in areas where prevalence of mild to moderate underweight children is greater than 25% and where parasites are known to be widespread, high priority should be given to deworming programme, data on prevalence of worms and trials of anthelmintic drugs are vital'.27