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Related to Anthelmintics: Albendazole, mebendazole, Helminths


McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



(also vermifuge, helminthagogue), a preparation used to treat worm diseases, or helminthiases. The action of different anthelmintics varies. Some preparations, such as Heptylresorcine and Phenasal, damage the cuticle (integument) of helminths, while other preparations, such as santonin, ditrazin, piperazine, and naphtammone, alter the tone and mobility of parasites. Anthelmintics expel helminths from the patient’s body and are used when helminths infest the intestine and its communicating organs (liver, pancreas). Anthelmintics are also used to kill helminths.

Piperazine acts on the neuromuscular system of ascarids, which are subsequently excreted with feces. Phenasal destroys the integument of various tapeworms, including beef tapeworms, dwarf tapeworms, and broad tapeworms. They are then digested in the intestine and their residue is excreted. Chloxyl kills Siberian liver fluke in the liver and pancreas. The parasite is then eliminated into the intestine. Other anthelmintics, such as ditrazin and antimony preparations, destroy helminths, such as filiariae and schistosomes, in the blood, lymphatics, and tissues. Some antihelmintics, such as ditrazin and Chloxyl, are produced chemically. Others are obtained from plants, for example, from Artemisia cina or the extract of male fern.


Krotov, A. I. Osnovy eksperimental’noi terapii gel’mintozov. Moscow, 1973.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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The resistance of worms to anthelmintics is a classic example of the evolutionary consequence of drug use.
Rotate anthelmintic classes annually; this helps reduce the drug resistance that develops.
In conclusion, this study showed that common nematodes, coccidian and acanthocephalan, all of veterinary importance, occur at various prevalence and intensity in pigs in Bamboutos, despite the use of anthelmintics and the implementation of a prophylaxis program by farmers.
(2012) stated that resistance to more recently introduced anthelmintics for ruminants nematode is an emerging problem throughout the world.
Statistical analysis using ANOVA showed that all three anthelmintics produce significantly different efficacy (p<0.05) on EPGF after 11th day of administration however, Piperazine had highest efficacy (p<0.05) followed by Ivermectin and Levamisole (Table 2).
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(14.) Hennessy D, Steel J.The influence of ruminal absorption on pharmacokinetic behavior of benzimidazole anthelmintics. Proc.
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