Evaluation of anthralin
in the treatment of alopecia areata.
GIVEN ITS LIMITED systemic toxicity, topical anthralin
is an acceptable second-line treatment option for pediatric alopecia areata (AA), according to Sean Z.
She returned with a large bag full of dermatologic samples, including Drithocreme (anthralin
), which can be an irritant.
Treatments include topical corticosteroids and retinoids, which reduce inflammation, salicylic acid to remove dead skin cells, and anthralin
, which slows cell growth and removes scales.
Topical management with topical corticosteroids, tar, psoralen ultraviolet A, ultraviolet B, anthralin
, keratolytics, and retinoids may try but unsatisfactory.
Topical immunotherapy or anthralin
have been used, essentially trying to get an inflammatory response in the scalp that alters the local immune environment, but these therapies have lots of issues with side effects and potential toxic effects.
Exclusion criteria were patients with severe psoriasis, scalp psoriasis, pustular psoriasis, and those receiving antipsoriatic drugs (vitamin [D.sub.3] analogs, corticosteroids, coal tar, anthralin
, photochemotherapy, and immunosuppressants).
Simple analogues of anthralin
: unusual specificity of structure and antiproliferative activity.
and bendiocarb are expected to have greater dermal than oral absorption.
Local treatment of psoriasis includes local corticosteroid therapy, vitamin D analogues, anthralin
preparations, tar and topical retinoids, calcineurin inhibitors, keratinolytics and emollients [28, 29].
In general, initial treatment of psoriasis involves application of a topical medicine, which could be a steroid preparation, retinoid (synthetic vitamin A), dithranol, calcipotriol (a vitamin D analog), anthralin
, or coal tar.