Previous studies showed that indole biodegradation occurred via the formation of (i) indoxyl, 2,3-dihydroxyindole, isatin, N-formylanthranilate, anthranilate, salicylate, and catechol ; (ii) 2,3-dihydroxyindole and anthranilate ; (iii) indoxyl, isatin, anthranilic acid
, and gentisate ; and (iv) indigo .
Compound 3 or 4-substituted anthranilic acid
when reacted with formamide at 125-130[degrees]C gave 3,4-dihydro-4-oxoquinazoline (see Scheme 8).
Yoshimura, "Pharmacological properties of N (3',4' dimethoxycinnamoyl) anthranilic acid
(N-5'), a new anti atopic agent," British Journal of Pharmacology, vol.
Segmented kinetics with an initial burst was also observed for the massive increase in anthranilic acid
(38.6% per year for the first 11.7 years), whereas choline (8.68% per year), arginine (2.52% per year), and serine (0.52% per year) increased in a linear fashion (Table 4).
N-aryl anthranilic acid
nucleus is an effective NSAID, used for skeletal muscle relax tent also pain relief agents.
Summary: Efficient and fast condensation of anthranilic amide or anthranilic acid
with various orthoesters have been carried out using a catalytic amount of Antimony(III) chloride (SbCl3) under microwave irradiation to afford a series of 2-substituted quinazolin-4(3H)-ones in good to excellent yields under solvent free condition.
Of the 17 chemicals, India's NDPS Act designates five as "Schedule A" substances (subject to the most stringent controls): acetic anhydride, ephedrine, pseudoephedrine, n-acetylanthranilic acid, and anthranilic acid
The next step is the conversion of N-formylkynurenine to L-kynurenine (L-KYN), a metabolite that will serve as substrate for various enzymes: kynureninase which produces anthranilic acid
(ANA), kynurenine aminotransferases (KAT I, II, and III), that catalyze the irreversible transamination from L-KYN to kynurenic acid (KYNA), and kynurenine 3-monooxygenase (KMO) that catalyzes the synthesis of 3-hydroxykynurenine (3-HK).
2-methyl-4H-1,3-benzoxazin-4-ones (2b/2c): A mixture of anthranilic acid
or 3, 5 dibromo anthranilic acid
(0.01 M) and acetic anhydride (0.02 M) were added to acetic acid (0.01 M).
Furosemide, an anthranilic acid
derivative, is one of the most potent diuretic drugs commercially available [1, 2].
The NDPS Act designates a total of 17 precursor chemicals as controlled substances, including five as Schedule A substances (the highest classification for controls): acetic anhydride; ephedrine; pseudoephedrine; n-acetylanthranilic acid; and anthranilic acid
. Domestic manufacture, transport, sale, possession, and international trade in designated precursor chemicals are controlled under the NDPS Act.