anticoagulant

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Related to Anti-coagulant: anticoagulant therapy, anticoagulant drugs

anticoagulant

(ăn'tēkōăg`yələnt), any of several substances that inhibit blood clot formation (see blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance, and other clotting factors. The coumarin derivatives compete with vitamin K, which is a necessary substance in prothrombin formation (see vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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). They are only effective after the body's existing supply of prothrombin is depleted. Another anticoagulant, heparin, is a polysaccharide (see carbohydratecarbohydrate,
any member of a large class of chemical compounds that includes sugars, starches, cellulose, and related compounds. These compounds are produced naturally by green plants from carbon dioxide and water (see photosynthesis).
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) found naturally in many cells. It acts in several ways: by preventing prothrombin formation; by preventing formation of fibrin, another clotting substance; and by decreasing the availability of a third clotting factor, thrombin. Heparin is obtained by extracting it from animal tissues. Anticoagulants are used to treat blood clots, which appear especially frequently in veins of the legs and pelvis in bedridden patients. Therapy helps to reduce the risk of clots reaching the lung, heart, or other organs. Heparin causes an instantaneous increase in blood-clotting time, and its effect lasts several hours.

anticoagulant

[¦an·tē‚kō′ag·yə·lənt]
(pharmacology)
An agent, such as sodium citrate, that prevents coagulation of a colloid, especially blood.

anticoagulant

1. acting to prevent or impair coagulation, esp of blood
2. an agent, such as warfarin, that prevents or impairs coagulation
References in periodicals archive ?
The results strongly suggest that oral anti-coagulants protect against dementia in AF patients.
Two anti-coagulants were used in the study, K3 EDTA and lithium heparin (LiHep), and slides were made either immediately or after periods of 4-6 hours, with the test results being analyzed to determine whether there was any correlation between the anticoagulant used and the sample processing time.
This is an interesting case of life-threatening Iatrogenic Haemothorax, which occurred due to a simple procedure like thoracocentesis in a patient who was under anti-coagulant therapy which was ignored and not stopped before the procedure.
Ruff said that more than half of A-fib patients are either not on an anti-coagulant or on an ineffective dose.
Methods: The retrospective study was conducted at Istanbul Hisar International Hosptial and comprised 63 male patients who were on anti-coagulant therapy for comorbidities and who underwent prostate vapourisation for benign prostate hyperplasia with 120 Watts potassium titanyl phosphate from November 2007 to December 2010.
It is developing a product which addresses a global need - nearly everyone I speak to knows someone who has had a stroke or a heart problem and has therefore been prescribed anti-coagulants.
Anti-coagulant drugs work well and safely, but the dosage effect must be regularly monitored.
BARTON replies: THE blue rat poison is usually the anti-coagulant type and animals who eat this can bleed to death.
Note: Because garlic is a powerful anti-coagulant (prevents bloodclotting), don't take it in large amounts if you have a clotting disorder, and consult with your health care practitioner if you take anti-coagulants, such as Coumadin, or therapeutic doses of aspirin.
Test kits for quality-of-life reducing conditions such as osteoporosis and cardio-vascular disease (thrombosis), plus an individual's sensitivity to anti-coagulant drugs are available from the company.
Microvisk is using the sensor technology in a tiny strip to monitor the blood clotting status of patients on warfarin, an anti-coagulant drug for people with heart conditions.
Cedars-Sinai Medical Centre apologised for what it called the "preventable error" that led to the twins and another unidentified child being given 10,000 units of the anti-coagulant Heparin, instead of the normal 10 units given to infants.