anticoagulant

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anticoagulant

(ăn'tēkōăg`yələnt), any of several substances that inhibit blood clot formation (see blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance, and other clotting factors. The coumarin derivatives compete with vitamin K, which is a necessary substance in prothrombin formation (see vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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). They are only effective after the body's existing supply of prothrombin is depleted. Another anticoagulant, heparin, is a polysaccharide (see carbohydratecarbohydrate,
any member of a large class of chemical compounds that includes sugars, starches, cellulose, and related compounds. These compounds are produced naturally by green plants from carbon dioxide and water (see photosynthesis).
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) found naturally in many cells. It acts in several ways: by preventing prothrombin formation; by preventing formation of fibrin, another clotting substance; and by decreasing the availability of a third clotting factor, thrombin. Heparin is obtained by extracting it from animal tissues. Anticoagulants are used to treat blood clots, which appear especially frequently in veins of the legs and pelvis in bedridden patients. Therapy helps to reduce the risk of clots reaching the lung, heart, or other organs. Heparin causes an instantaneous increase in blood-clotting time, and its effect lasts several hours.

anticoagulant

[¦an·tē‚kō′ag·yə·lənt]
(pharmacology)
An agent, such as sodium citrate, that prevents coagulation of a colloid, especially blood.

anticoagulant

1. acting to prevent or impair coagulation, esp of blood
2. an agent, such as warfarin, that prevents or impairs coagulation
References in periodicals archive ?
Friberg noted, "Doctors should not tell their patients to stop using oral anti-coagulants without a really good reason.
When performing bioanalytical test procedures, it is important to choose wisely when considering parameters such as the sampling tubes, anti-coagulant used, the test conditions, the sample processing times prior to the test, and the sample processing and test methods used.
People metabolize warfarin at different rates, making it necessary to repeatedly check a patient's clotting ability to reduce the risk of excessive bleeding while maintaining an effective anti-coagulant level.
Methods: The retrospective study was conducted at Istanbul Hisar International Hosptial and comprised 63 male patients who were on anti-coagulant therapy for comorbidities and who underwent prostate vapourisation for benign prostate hyperplasia with 120 Watts potassium titanyl phosphate from November 2007 to December 2010.
In a preliminary hearing, Charlotte Jones, on behalf of the trust, had told the court that a "deliberate decision" had been made not to give Mrs Harrison fast acting anti-coagulants, as there was a risk of internal bleeding in her heart which could have had fatal consequences with a very rapid onset.
They review efforts to coat implant material with biological anti-coagulants such as heparin, or anti-fouling molecules like polyethylene oxide.
I had a stiff calf and it got progressively worse," said Flintoff, who is on a course of anti-coagulants and will be on crutches for a minimum of one more month.
Certain coloured ingredients are associated with health benefits, such as black and purple foods said to be rich in anti-coagulants," said Mintel consultant Carla Ogeia.
However, some people can't take anti-coagulants for prolonged periods, so they are better off receiving the bare metal stents," Dr.
Anti-coagulants were used on 65 women during the second trimester (61 on an oral agent and 4 on heparin), and 60 received an anticoagulant during the third trimester (57 on an oral agent and 3 on heparin).
It may interact with anti-inflammatory drugs, corticosteriods, beta-blockers, antipsychotics, anti-coagulants and drugs to control epilepsy.
The plasma, fortified with anti-coagulants and antibiotics, was poured into a mould for freezing in a custom-built fridge.