We are concerned about using vaginal estrogen in women who have had aromatase inhibitor (Al) therapy; their estrogen levels are so low that absorbing even a small amount might make a difference in terms of effectiveness of AL For women who need more than lubricants or vaginal moisturizers, particularly those taking anti-estrogen therapy
(aromatase therapy), the use of low-dose vaginal hormones may be considered on an individual basis, but should include the oncologist in decision making.
Her circulatory tumor DNA (ctDNA) was studied through Guardant 360 Lab, on 6/25/15, which showed positive NF-1, and APC, likely due to the exposure to anti-estrogen therapy
. Following further treatments with MTET (Multi-targeted Epigenetic therapy), her Guardant 360 was repeated and showed no ctDNA (Figure 1).
The two broad classes of anti-estrogen therapy
include SERMs and Als.
"If a woman is dealing with tremendous hot flashes due to anti-estrogen therapy
, there are several remedies that might be explored (such as black cohosh, Effexor, clonidine, acupuncture, etc.)," adds Sara Hurvitz, MD, director of the UCLA Santa Monica Hematology Oncology at 2020 group.
Led by Elisabetta Rapiti of the Geneva Cancer Registry, the study compared lung cancer incidence and mortality among breast cancer patients who were and were not treated with anti-estrogen therapy
SAN ANTONIO -- Women treated with anti-estrogen therapy
for breast cancer appeared to have a reduced risk of dying later from lung cancer in a Swiss registry study, suggesting that the agents may be protective, Dr.
This work builds on previous studies that had suggested estrogens have a role in lung cancer development and progression," said Elisabetta Rapiti, M.D., M.P.H., medical researcher with the Geneva Cancer Registry, University of Geneva, Switzerland.Rapiti and colleagues evaluated whether anti-estrogen therapy
for breast cancer patients reduced their risk of subsequently developing and/or dying from lung cancer.The study included 6,715 women living in the Geneva canton of Switzerland who were diagnosed with breast cancer, between 1980 and 2003.
Recent RCT showed no benefit Other: Bellergal, All have been advocated but no methyldopa, evening positive trials for any evidence primrose oil, ginseng, of effect wild yam extract, mat quan, flaxseed * Trials conducted only with patients with breast cancer and interventional menopause, most of whom were on anti-estrogen therapy
. ([dagger]) See page 290 for a description of strength of recommendation.
But with secondary, or metastatic, tumors often difficult to find or biopsy -- and with many metastases lacking estrogen receptors even when the primary tumor may have many -- months could pass before a physician finds that anti-estrogen therapy
is not working.
Forty-six percent of the women received anti-estrogen therapy
, primarily tamoxifen.
If estrogen and/or progesterone receptors are present, then it is likely that the patient will be treated with anti-estrogen therapy
, also called hormonal therapy.