antinuclear antibody

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antinuclear antibody

[¦an·tē¦nü·klē·ər ′an·tə‚bäd·ē]
(immunology)
Antibody to deoxyribonucleic acid, ribonucleic acid, histone, or nonhistone proteins found in the serum of individuals with certain autoimmune diseases. Abbreviated ANA.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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- US-based research and advisory specialist Technavio analysts forecast the global anti-nuclear antibody (ANA) testing market to grow at a CAGR of more than 7% during the forecast period, according to their latest report, the company said.
This challenge has led to a proposed consensus nomenclature for IIF patterns available on the international consensus of anti-nuclear antibody pattern (ICAP) website (http://www.ANApatterns.org).
Seroconversion of anti-nuclear antibody and double stranded deoxyribonucleic acid has been observed in patients exposed to TNF-[alpha] antagonists with an incidence of 25% to 80% and 5% to 15%, respectively.
The anti-nuclear antibody test was positive at a titre of 1:2 560, as was the anti-U1RNP antibody, and anti-Ro antibody.
The most helpful markers for diagnosing WG are by far anti-nuclear antibody (ANA), cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA), and anti-proteinase 3 antibodies (anti-PR3).
The anti-nuclear antibody was weakly positive at a titer of 1:40, while the anti-smooth muscle antibody, anti-mitochondrial antibody and anti-liver kidney microsomal antibody were all negative.
Laboratory findings in patients with levamisole-induced vasculitis include leukopenia (leukocyte count <4000/[micro]L), neutropenia (neutrophil count <1500/[micro]L), agranulocytosis (neutrophil count <500/[micro]L), elevated erythrocyte sedimentation rate, normal coagulation studies, and positive autoantibodies including p- and c-ANCAs, anti-nuclear antibody, and lupus anticoagulant.
High levels of anti-nuclear antibody (ANA) and anti-neutrophilic cytoplasmic antibody (ANCA) and other connective tissue antibodies in patients with autoimmune thyroid disorder and ophthalmopathy support the view that "Graves' disease is a collagen-like disorder." It is controversial whether Graves' disease should be considered as a collagen tissue disease involving the thyroid, muscle tissue, and connective tissue.
Anti-nuclear antibody (ANA) positivity was seen in 80% of the patients.
Studies for c-ANCA, anti-proteinase 3 (PR3), anti-GBM, cryoglobulins, complement levels, anti-nuclear antibody, rheumatoid factor, hepatitis A, B, and C, and creatinine kinase were normal.
Abbreviations PBC: Primary biliary cirrhosis SNP: Single nucleotide polymorphism GWAS: Genome-wide association study IL12: Interleukin12 STAT4: Signal transducer and activator of transcription 4 AMA: Anti-mitochondrial antibody ANA: Anti-nuclear antibody PBMCs: Peripheral blood mononuclear cells LD: Linkage disequilibrium Pc: Corrected P OR: Odds ratio CI: Confidence interval.