Antispasmodic

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antispasmodic

[¦an·tē‚spaz′mäd·ik]
(pharmacology)
An agent, such as benzyl benzoate, that relieves convulsions and the pain of muscular spasms.

Antispasmodic

 

one of a group of pharmacological substances with various chemical structures that induce the relaxation of the smooth muscles of, for example, the blood vessels, bronchi, and gastrointestinal, biliary, and urinary tracts.

Antispasmodics may be, according to their mechanism of action, neurotropic or musculotropic. Neurotropic agents include cholinolytics, for example, such m-cholinolytics as atropine, spasmolytin, thiphen, aprophen, and diprophen. Conventionally, they also include sympathomimetics (Adrenalin, ephedrine, Is-adrine [Aleudrin]), which relax the smooth muscles of the bronchi, intestines, and other organs by exciting sympathetic nerves. Musculotropic antispasmodics, including papaverine and drotav-erinum, directly act on the smooth muscles.

Antispasmodics are used to treat many diseases accompanied by the intensified contraction of the smooth muscles, including asthma, renal colic, and spasms of the cerebral blood vessels.

REFERENCES

Kuznetsov, S. G., and S. N. Golikov. Sinteticheskie alropinopodobnye veshchestva. Leningrad, 1962. (Bibliography.)
Wesselius de Casparis, A. “Neurotropic Versus Musculotropic Antispasmodics.” Medicamundi, 1962, vol. 8, no. 5, pp. 92–98. (Bibliography.)

V. V. ZAKUSOV

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Decline in frequency of the colic episodes in combination therapy marks the anti-spasmodic role of added phloroglucinol.6 Decline in number of patients with the colic episode(s) in the combination (n=6; 18.8% compared to monotherapy n=14; 43.8%) is steeper than parecoxib (n =17; 14.3%) and parecoxib plus phloroglucinol (n=7; 6.1%) of a published data.18 It appears that phloroglucinol becomes more effective when it is in partnership with tamsulosin.
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Horne here delineates a confrontation between Romantic-style poetics and a more restrained model of composition that might be called anti-Spasmodic: The unrepressed vigour of imagination,--and the graceful display of philosophical thought; the splendour of great and original imagery,--and the level dignity of the operations of the understanding; the passion of poetry,--and the sound sense of poetry; are proposed to be discussed in this essay.