Speaking about the study, senior author Daniel Kreisel said, "Antibody-mediated rejection
is a vexing problem that is increasingly being acknowledged as an important cause of lung failure after transplantation."
Older kidney transplant patients experience less antibody-mediated rejection
: A retrospective study of patients with mild to moderate sensitization.
(ABMR) was defined when there was (1) histological evidence of tissue injury, (2) C4d positivity, and (3) the detection of circulating anti-HLA donor-specific antibodies.
Abbreviations ABMR: Antibody-mediated rejection
eGFR: Estimated glomerular filtration rate OPSI syndrome: Overwhelming postsplenectomy infection syndrome IVIG: Intravenous immunoglobulins.
Singer et al., "The use of antibody to complement protein C5 for salvage treatment of severe antibody-mediated rejection
," American Journal of Transplantation, vol.
Pre- and post-operative plasmapheresis results in a dramatic drop in DSA levels, which reduces the risk of hyper-acute rejections and early antibody-mediated rejections
. Intravenous immunoglobulins will neutralise DSA for weeks.
. Curr Opin Organ Transplant.
Six patients lost their grafts because of allograft dysfunction, in three of whom acute antibody-mediated rejection
(N = 2) and thrombosis of allograft vein were confirmed histologically.
Humoral or antibody-mediated rejection
manifest as any one of the following three types (10,11)
Pathologists and other clinicians from Europe discuss antibody-mediated rejection
of organ allografts, the maternal death autopsy, the classification and treatment of non-small-cell lung carcinoma, the pathology of obesity, the role of the histopathologist in stratified medicine for cancer, the mucosal pathology of the gastric cardia and Barrett's esophagus, the pathology of regenerative and neoplastic hepatocellular nodules, serrated lesions of the colon and rectum, the pathology of chronic inflammatory bowel disease, the diagnosis and therapy for gastrointestinal MALT (mucosa-associated lymphoid tissue) lymphoma, medical revalidation for histopathologists in the UK, molecular testing for human papillomavirus, and the role of tensins in health and disease.
(9) Most allograft damage is mediated though the activation of complement; C4d deposition is widely accepted as a marker for antibody-mediated rejection
in renal allografts.
is a type of rejection that occurs when a patient has antibodies circulating in their blood against the donor organ (i.e.