anticoagulant

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Related to Anticoagulant drug: warfarin

anticoagulant

(ăn'tēkōăg`yələnt), any of several substances that inhibit blood clot formation (see blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance, and other clotting factors. The coumarin derivatives compete with vitamin K, which is a necessary substance in prothrombin formation (see vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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). They are only effective after the body's existing supply of prothrombin is depleted. Another anticoagulant, heparin, is a polysaccharide (see carbohydratecarbohydrate,
any member of a large class of chemical compounds that includes sugars, starches, cellulose, and related compounds. These compounds are produced naturally by green plants from carbon dioxide and water (see photosynthesis).
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) found naturally in many cells. It acts in several ways: by preventing prothrombin formation; by preventing formation of fibrin, another clotting substance; and by decreasing the availability of a third clotting factor, thrombin. Heparin is obtained by extracting it from animal tissues. Anticoagulants are used to treat blood clots, which appear especially frequently in veins of the legs and pelvis in bedridden patients. Therapy helps to reduce the risk of clots reaching the lung, heart, or other organs. Heparin causes an instantaneous increase in blood-clotting time, and its effect lasts several hours.

anticoagulant

[¦an·tē‚kō′ag·yə·lənt]
(pharmacology)
An agent, such as sodium citrate, that prevents coagulation of a colloid, especially blood.

anticoagulant

1. acting to prevent or impair coagulation, esp of blood
2. an agent, such as warfarin, that prevents or impairs coagulation
References in periodicals archive ?
Initially, researchers believed the use of anticoagulant drug therapy would adversely affect the success rate of UGCR.
The anticoagulant drug warfarin, which lowers the risk of clot formation and therefore a stroke.
(iii) Rivaroxiban: It is the first oral anticoagulant drug direct inhibitor of activated factor X of clotting.
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The company's products are used particularly for monitoring the anticoagulant drug Warfarin, which is prescribed extensively in patients who have suffered or may potentially suffer from thrombosis.
Failure to fill these tubes appropriately may result in erroneous test results, which may adversely affect anticoagulant drug therapy.
Although it was more than a year ago (July 1997) that Barr began shipping dosages in seven strengths of the anticoagulant drug, its confrontation with DuPont Pharmaceuticals Co., which markets the drug under the Coumadin brand name, even preceded Barr's March 1997 marketing clearance for the product.
Reddy's Laboratories stated that Fondaparinux is a generic version of the anticoagulant drug Arixtra, which is approved in the US and Europe for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE).
Among patients taking the anticoagulant drug warfarin (Coumadin), obese patients are at much higher risk than non-obese patients of a major bleeding event, according to research presented in May 2015 at the American Heart Association's Arteriosclerosis, Thrombosis and Vascular Biology/ Peripheral Vascular Disease Scientific Sessions.

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