anticoagulant

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Related to Anticoagulant drug: warfarin

anticoagulant

(ăn'tēkōăg`yələnt), any of several substances that inhibit blood clot formation (see blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance, and other clotting factors. The coumarin derivatives compete with vitamin K, which is a necessary substance in prothrombin formation (see vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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). They are only effective after the body's existing supply of prothrombin is depleted. Another anticoagulant, heparin, is a polysaccharide (see carbohydratecarbohydrate,
any member of a large class of chemical compounds that includes sugars, starches, cellulose, and related compounds. These compounds are produced naturally by green plants from carbon dioxide and water (see photosynthesis).
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) found naturally in many cells. It acts in several ways: by preventing prothrombin formation; by preventing formation of fibrin, another clotting substance; and by decreasing the availability of a third clotting factor, thrombin. Heparin is obtained by extracting it from animal tissues. Anticoagulants are used to treat blood clots, which appear especially frequently in veins of the legs and pelvis in bedridden patients. Therapy helps to reduce the risk of clots reaching the lung, heart, or other organs. Heparin causes an instantaneous increase in blood-clotting time, and its effect lasts several hours.

anticoagulant

[¦an·tē‚kō′ag·yə·lənt]
(pharmacology)
An agent, such as sodium citrate, that prevents coagulation of a colloid, especially blood.

anticoagulant

1. acting to prevent or impair coagulation, esp of blood
2. an agent, such as warfarin, that prevents or impairs coagulation
References in periodicals archive ?
Initially, researchers believed the use of anticoagulant drug therapy would adversely affect the success rate of UGCR.
The company's products are used particularly for monitoring the anticoagulant drug Warfarin, which is prescribed extensively in patients who have suffered or may potentially suffer from thrombosis.
Failure to fill these tubes appropriately may result in erroneous test results, which may adversely affect anticoagulant drug therapy.
Although it was more than a year ago (July 1997) that Barr began shipping dosages in seven strengths of the anticoagulant drug, its confrontation with DuPont Pharmaceuticals Co.
In fact, after his first day of shooting, Sorbo was forced to spend a night in a hospital for observation because of an adverse reaction to the initial anticoagulant drug he was given to treat the aneurysm.
And, when taking any anticoagulant drug, seek medical care immediately if you have symptoms of bleeding, such as bloody or tarry stools, red or brown urine, coughing up or vomiting blood or material that looks like coffee grounds, or nose bleeds.
Your bleeding risk can be much higher if you take an anticoagulant drug, such as warfarin (Coumadin *), and also use aspirin, for example.
It is the most commonly used anticoagulant drug, with about 21 million prescriptions filled annually in the U.
NICE on Wednesday said that it is recommending Bayer's anticoagulant drug Xarelto to help reduce the risk of stroke in certain patients.
When researchers reported earlier at the American College of Cardiology's annual meeting results from the TRA 2P-TIMI 50 trial, which tested a novel anticoagulant drug, vorapaxar, for preventing cardiovascular death, myocardial infarction (MI), and stroke in stable patients with cardiovascular disease, the results showed a questionable balance between benefit and bleeding risk that looked good only if you squinted and confined the analysis to patients with just a history of MI, no history of stroke, a body weight of at least 60 kg, and, ideally, those who were younger than 75 years old.
A Warfarin (Coumadin) is an anticoagulant drug that helps inhibit the formation of blood clots to prevent cardiovascular events, such as strokes, heart attacks and pulmonary embolism (a blood clot that travels to the lungs).

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