Anticonvulsant


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anticonvulsant

[‚an·tē·kən′vəl·sənt]
(pharmacology)
An agent, such as Dilantin, that prevents or arrests a convulsion.

Anticonvulsant

 

one of a group of medicinal preparations having different chemical compositions and capable of preventing or relieving convulsions. Anticonvulsants include a number of substances that act as hypnotics and sedatives, for instance, bromides, chloral hydrate, magnesium sulfate, and phenobarbital. Other substances are selectively anticonvulsant, for example, diphenin, Hexamidine (lepsiral), Trimethin (epidione), and chloracon. Anticonvulsants are used mainly in treating epilepsy.

REFERENCE

Mashkovskii, M. D. Lekarstvennye sredstva, 7th ed., part 1. Moscow, 1972.
References in periodicals archive ?
ORLANDO -- Patients who experienced sudden cardiac death had a significantly higher rate of treatment with a sodium channel-blocking, anticonvulsant drug, compared with people who did not have sudden death, in a case-control study of more than 10,000 people.
As ongoing anticonvulsant studies continue to accrue sample size, the panel's recommendations at present are as follows:
After this meta-analysis was published, Danish researchers came out with a study comparing lithium and anticonvulsants in suicide prevention in bipolar patients (Bipolar Disord.
Epilepsy continues to be a neurological disorder awaiting safer drugs with improved anticonvulsant and anti-epileptogenic effectiveness as currently available drugs fail to provide adequate control of epileptic seizures in about one-third of patients and do not prevent progressive epileptogenic changes are not well understood (Cockerell, 1996).
In addition to the recommendation against prophylactic anticonvulsant therapy, the guideline also addresses the use of intermittent antipyretics.
Roughly 90% of patients with anticonvulsant hypersensitivity syndrome develop leukocytosis with eosinophilia, and some develop leukocytosis with agranulocytosis.
The abolition of tonic hind limb extension (THLE) is taken as an index of anticonvulsant activity.
copticum exerted anticonvulsant property at lower doses (200-600 mg/kg) than did caraway, this might be due to the different models of seizures and animals (rats vs.
5, 5, 10, 20 and 40 mg kg) on Primphos-induced seizures showed that this drug dose-dependently reduced the Primphos-induced seizures (Graph 1 and 2) Most anticonvulsant effect of nimodipine on the mortality and severity of seizures with a dose of 40 mg/kg was observed (Graph 3 and Table 1).
And two of the drugs in combination, the anticonvulsant zonisamide and the glucocorticoid methylprednisolone, showed comparable hearing protection at much lower doses than when administered alone.
EMPACT should be classified as a specific entity among the erythema multiformlike drug reactions as it only appears after radiotherapy and seizure prophylaxis with the anticonvulsant phenytoin.