Anticonvulsant

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anticonvulsant

[‚an·tē·kən′vəl·sənt]
(pharmacology)
An agent, such as Dilantin, that prevents or arrests a convulsion.

Anticonvulsant

 

one of a group of medicinal preparations having different chemical compositions and capable of preventing or relieving convulsions. Anticonvulsants include a number of substances that act as hypnotics and sedatives, for instance, bromides, chloral hydrate, magnesium sulfate, and phenobarbital. Other substances are selectively anticonvulsant, for example, diphenin, Hexamidine (lepsiral), Trimethin (epidione), and chloracon. Anticonvulsants are used mainly in treating epilepsy.

REFERENCE

Mashkovskii, M. D. Lekarstvennye sredstva, 7th ed., part 1. Moscow, 1972.
References in periodicals archive ?
Aims and Objectives: The objective was to evaluate the anticonvulsant effect of ethanolic extract of leaves of OS and to compare the anticonvulsant effect with the standard sodium valproate in electrically and chemically induced epileptic animal models.
The etiology is primarily attributed to drugs with antimicrobials, anticonvulsants, and antipyretics being the most common culprits7.
In contrary to the common observation of carbamazepine being the commonest drug causing ADR among anticonvulsants, phenytoin was found to be more commonly attributed in ADR in this study.
In the analysis of the anticonvulsants by the underlying cause of overdose; among the patients who ingested carbamazepine, the overdose was intentional in 75% (n=21), and unintentional in 21.
The anticonvulsant effect of Guaifenesin was assessed in an animal model of PTZ-induced seizure.
In summary, this study showed that nimodipine (voltage-dependent calcium channel antagonist type L) decreased clonic and tonic seizures from Primphos in mice is probably the main mechanism anticonvulsant related to block calcium channels and reduce calcium flow within neurons.
And two of the drugs in combination, the anticonvulsant zonisamide and the glucocorticoid methylprednisolone, showed comparable hearing protection at much lower doses than when administered alone.
EMPACT should be classified as a specific entity among the erythema multiformlike drug reactions as it only appears after radiotherapy and seizure prophylaxis with the anticonvulsant phenytoin.
A recent scholarly review by a group of Italian psychiatrists led by Icro Maremmani noted that there are few studies of the role of anticonvulsants in SUD treatment.
The risks of attempted or completed suicidal acts or violent deaths were compared between patients aged 15 and older who had initiated treatment with one of two reference anticonvulsants (topiramate or carbamazepine) and patients who had initiated treatment with any of 13 other anticonvulsants.
In what they described as the first study to directly compare suicide risks with different anticonvulsants given in routine care, the investigators reported finding "increased risk for suicidal acts beginning within the first 14 days of treatment initiation.
The risk of attempted or completed suicidal acts or violent deaths were compared between patients aged 15 and older who had initiated treatment with one of two reference anticonvulsants (topiramate or carbamazepine) and patients who had initiated treatment with any of 13 other anticonvulsants.