, sedative and muscle relaxant effects of carbenoxolone in mice.
Jiang, "Synthesis and anticonvulsant
activity of 8-alkoxy-5,6-dihydro-4H-[1,2,4] triazolo[4,3-a]benzazepin-1-one derivatives," European Journal of Medicinal Chemistry, vol.
They displayed a considerable safety profile in scPTZ induced seizure also indicative of the efficiency of both the compounds as broad spectrum anticonvulsants
The association among anticonvulsants
, decreased bone mineral density, and increased risk of fracture is well-established in the literature.
Bis-Schiff bases derivatives possess miscellaneous pharmacological activities such as anticancer , antifungal, herbicidal activities [2,3], and antibacterial , while Schiff bases of various heterocycles were reported to possess cytotoxic , antiproliferative , anticonvulsant
, and anticancer activities .
In the analysis of the anticonvulsants
by the underlying cause of overdose; among the patients who ingested carbamazepine, the overdose was intentional in 75% (n=21), and unintentional in 21.4% (n=6), while these rates were 95.0% (n=19) and 5.0% (n=1) for valproic acid and 35.7% (n=5) and 64.3% (n=9) for phenytoin respectively.
hypersensitivity syndrome associated with carbamazepine administration: case series.
(80%) formed the major drug group causative for DHS in this study with the rest 20% being caused by dapsone.
-- Black box warnings on antipsychotics led to a decrease in their use to treat patients with dementia, without a commensurate increase in use of antianxiety or other psychotropic agents but with a rise in the use of anticonvulsant
therapies, some of which appear to be riskier than the antipsychotics in older patients.
Arylsemicarbazones featuring the general structural skeleton III (Figure 1) have been recognized as a promising pharmacophore for anticonvulsants
and a sizable number of arylsemicarbazone derivatives showed anticonvulsant
([1,7]) However, despite extensive research on new anticonvulsants
, no full treatment has yet been found for epilepsy.
Most people who have bipolar disorder take more than one medication including, along with lithium and/or an anticonvulsant
, a medication for accompanying agitation, anxiety, depression, or insomnia.