antidepressant

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Related to Antidepressant drugs: Zoloft, citalopram, Prozac, Celexa, Lexapro

antidepressant,

any of a wide range of drugs used to treat psychic depressiondepression,
in psychiatry, a symptom of mood disorder characterized by intense feelings of loss, sadness, hopelessness, failure, and rejection. The two major types of mood disorder are unipolar disorder, also called major depression, and bipolar disorder, whose sufferers are
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. They are given to elevate mood, counter suicidal thoughts, and increase the effectiveness of psychotherapypsychotherapy,
treatment of mental and emotional disorders using psychological methods. Psychotherapy, thus, does not include physiological interventions, such as drug therapy or electroconvulsive therapy, although it may be used in combination with such methods.
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. Before the introduction of such drugs in the late 1950s, most patients with major depression had no recourse but hospitalization; only 45% improved after one year. In contrast, 80%–90% of such patients can expect significant relief from depression with one of the medications now prescribed.

Antidepressants act on the flow of the neurotransmitters epinephrineepinephrine
, hormone important to the body's metabolism, also known as adrenaline. Epinephrine, a catecholamine, together with norepinephrine, is secreted principally by the medulla of the adrenal gland.
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, serotoninserotonin
, organic compound that was first recognized as a powerful vasoconstrictor occurring in blood serum. It was partially purified, crystallized, and named in 1948, and its structure was deduced a year later.
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, and norepinephrinenorepinephrine
, a neurotransmitter in the catecholamine family that mediates chemical communication in the sympathetic nervous system, a branch of the autonomic nervous system.
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 across neural synapsessynapse
, junction between various signal-transmitter cells, either between two neurons or between a neuron and a muscle or gland. A nerve impulse reaches the synapse through the axon, or transmitting end, of a nerve cell, or neuron.
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. Common antidepressants include monamine oxidase inhibitors (MAOIs) such as isocarboxazid (Marplan), tricyclics such as imipramine (Tofranil) and amitriptyline (Elavil), and the newer selective serotonin reuptake inhibitors (SSRIs) as fluoxetine (Prozac) and sertraline HCL (Zoloft). Venlafaxine (Effexor) inhibits both serotonin and norepinephrine reuptake.

The choice of antidepressant often has more to do with its side effects (variously sedation, constipation, hypotension, tachycardia, weight gain, sexual dysfunction) than efficacy, as they are generally regarded to be equally effective. The newer drugs, especially SSRIs, are tolerated better and are currently by far the most widely prescribed, but SSRIs also appear to be less effective in children and teenagers and may cause some of them to become suicidal.

antidepressant

[‚an·tē·di′pres·ənt]
(pharmacology)
A drug, such as imipramine and tranylcypromine, that relieves depression by increasing central sympathetic activity.

antidepressant

any of a class of drugs used to alleviate depression
References in periodicals archive ?
Food and Drug Administration (FDA) of its Abbreviated New Drug Application (ANDA) for Aripiprazole Oral Solution 1 mg/mL, the generic version of the antidepressant drug ABILIFY[sup.
In preliminary clinical trials, Therapeutic Lifestyle Change has resulted in a rate of favorable response that is over three times higher than that of antidepressant drugs alone.
SSRI antidepressant drugs, such as Lexapro and Prozac, were banned in the UK for use on children under 18 some years ago due to the sharply increased risk of suicidal behavior in children, among other dangerous side-effects.
It's worth considering how so many antidepressant drugs have been prescribed.
Here's some depressing news about antidepressant drugs.
Often antidepressant drugs are used to counter symptoms which, if left untreated, can last as long as one year.
Subjects who were treated with antidepressant drugs were not at increased risk of diabetes, but it remained unclear whether or not treating depression affected diabetes risk.
Tricyclic antidepressant drugs block the reuptake of serotonin and norepinephrine, and that action is thought to be the basis of their beneficial effects in patients with depression.
Prozac, Paxil, and Zoloft are just a few antidepressant drugs called SSRIs (selective serotonin reuptake inhibitors).
ANNA Nicole Smith's 20-year-old son died from the accidental effect of methadone and two antidepressant drugs interacting in his system, according to a well-known American pathologist who conducted a private autopsy.
Some antidepressant drugs do produce painful withdrawal symptoms, and it is unconscionable that some patients are given these medications without appropriate warnings and without first having tried other, less problematic treatments.
From their report of Paul Ekman's research, one can even predict that some pharmaceutical companies that earn millions from the sales of antidepressant drugs probably would be happier if other reviewers and I did not help you to find this book.