antigenic determinant

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antigenic determinant

[‚an·tə¦jen·ik di′tər·mə·nənt]
(immunology)
The portion of an antigen molecule that determines the specificity of the antigen-antibody reaction.
References in periodicals archive ?
As all the surface SGPs act as blood group antigenic determinants and receptor sites for viruses, bacteria and parasites, the presence of higher number of SGPs within the membrane of goat, buffalo and pig erythrocyte indicates the higher immunological response of the animals as compared to human.
These CAP-RASTs are 80-90% specific, with a lower sensitivity, but react only with the major antigenic determinants (allergy to minor determinants is tested by skin prick testing).
VP1 residue 145 has previously been identified as a key antigenic determinant, of which substitution can significantly affect the neutralizing activity (23,38).
Focusing on the epitope information, using N protein-specific mAbs we thoroughly mapped the antigenic determinants distributed on the SARS-CoV N protein.
Antibodies with specific recognition for specific antigenic determinants could now be prepared.
The L segment encodes the RNA-dependent RNA polymerase; antigenic determinants are the M-encoded viral surface glycoproteins Gn and Gc, which are responsible for viral attachment, cell fusion, hemagglutination, and the induction of neutralizing antibodies, and the S-encoded nucleocapsid protein N, which plays a role in complement fixation (6).
The development of an antibody-based ELISA test to type haptoglobin has been hampered by the apparent lack of antigenic determinants unique to either allelic protein product.
Antibody responses to antigenic determinants of influenza virus hemagglutinin.
To compare with IAPP immunoreactivity measured by another assay detecting different antigenic determinants, the same samples were assayed by the solid amylin enzyme immunoassay (Amylin Pharmaceuticals Inc) without extraction (4).