antigenic drift


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Related to antigenic drift: Original antigenic sin

antigenic drift

[‚an·tə¦jen·ik ′drift]
(immunology)
Minor change of an antigen on the surface of a pathogenic microorganism.
References in periodicals archive ?
Apart from the winter influenza season in 2014/15, no antigenic drift was detected in other seasons.
Analysis of antigenic drift in recently isolated influenza A (H1N1) viruses using monoclonal antibody preparations.
The Influenza A Virus (IAV) undergoes major and minor genetic variations, the yearly antigenic drift resulting in as minor as a single amino acid mismatch.
Current influenza vaccines may be safe and immunogenic, but they are highly vulnerable to antigenic drift and shift, which compromise efficacy and require reformulation and repeated immunization.
During the 2009/2010 Northern Hemisphere influenza season, little antigenic drift occurred in circulating H1N1 (7) and the clinical manifestations remain generally mild.
These viruses are able to mutate and change very rapidly in a host due to their ability to undergo antigenic drift and/or antigenic shift.
The findings in mice, using a strain of seasonal influenza virus first isolated in 1934, also suggest that antigenic drift might be slowed by increasing the number of children vaccinated against influenza.
This strategy, known as antigenic drift, works well as a short-term survival tactic for the virus: the speed with which slight variations develop keeps populations susceptible to infection.
Frequent antigenic change, known as antigenic drift, is caused by mutations during reproduction of the virus, and results in new variants of influenza.
No significant antigenic drift of novel H1N1 virus away from what is in the vaccine has been encountered so far in the United States, he said.
Antigenic drift and shift as they relate to epidemics, pandemics and vaccine effectiveness.
But, even though we know which strains cause the flu and have a vaccine that prevents it, the vaccine must be reformulated every year because the strains regularly mutate through a gradual process called antigenic drift.