Anthelmintic

(redirected from Antihelminthic drug)
Also found in: Dictionary, Thesaurus, Medical.
Related to Antihelminthic drug: anthelmintic resistance, Anthelmintic drugs

anthelmintic

[¦an·thel¦min·tik]
(pharmacology)

Anthelmintic

 

(also vermifuge, helminthagogue), a preparation used to treat worm diseases, or helminthiases. The action of different anthelmintics varies. Some preparations, such as Heptylresorcine and Phenasal, damage the cuticle (integument) of helminths, while other preparations, such as santonin, ditrazin, piperazine, and naphtammone, alter the tone and mobility of parasites. Anthelmintics expel helminths from the patient’s body and are used when helminths infest the intestine and its communicating organs (liver, pancreas). Anthelmintics are also used to kill helminths.

Piperazine acts on the neuromuscular system of ascarids, which are subsequently excreted with feces. Phenasal destroys the integument of various tapeworms, including beef tapeworms, dwarf tapeworms, and broad tapeworms. They are then digested in the intestine and their residue is excreted. Chloxyl kills Siberian liver fluke in the liver and pancreas. The parasite is then eliminated into the intestine. Other anthelmintics, such as ditrazin and antimony preparations, destroy helminths, such as filiariae and schistosomes, in the blood, lymphatics, and tissues. Some antihelmintics, such as ditrazin and Chloxyl, are produced chemically. Others are obtained from plants, for example, from Artemisia cina or the extract of male fern.

REFERENCE

Krotov, A. I. Osnovy eksperimental’noi terapii gel’mintozov. Moscow, 1973.

N. N. PLOTNIKOV

References in periodicals archive ?
If these factors might intensify parasite transmission, the implementation of basic sanitation associated with the widespread use of antihelminthic drugs, often cheap and readily available in the health services, might help to reduce prevalence.
Albendazole is a broad-spectrum antihelminthic drug which is safe and effective in treating Strongyloides stercoralis infection.
Fifty-eight patients (50%) were treated with oral antimicrobial drugs; 13 patients (11%) were prescribed chloroquine, and 2 patients (2%) received an antihelminthic drug.
Albendazole: This well-known antihelminthic drug was shown to destroy the adult filarial worms when given in doses of 400 mg twice daily for two weeks.