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(also vermifuge, helminthagogue), a preparation used to treat worm diseases, or helminthiases. The action of different anthelmintics varies. Some preparations, such as Heptylresorcine and Phenasal, damage the cuticle (integument) of helminths, while other preparations, such as santonin, ditrazin, piperazine, and naphtammone, alter the tone and mobility of parasites. Anthelmintics expel helminths from the patient’s body and are used when helminths infest the intestine and its communicating organs (liver, pancreas). Anthelmintics are also used to kill helminths.

Piperazine acts on the neuromuscular system of ascarids, which are subsequently excreted with feces. Phenasal destroys the integument of various tapeworms, including beef tapeworms, dwarf tapeworms, and broad tapeworms. They are then digested in the intestine and their residue is excreted. Chloxyl kills Siberian liver fluke in the liver and pancreas. The parasite is then eliminated into the intestine. Other anthelmintics, such as ditrazin and antimony preparations, destroy helminths, such as filiariae and schistosomes, in the blood, lymphatics, and tissues. Some antihelmintics, such as ditrazin and Chloxyl, are produced chemically. Others are obtained from plants, for example, from Artemisia cina or the extract of male fern.


Krotov, A. I. Osnovy eksperimental’noi terapii gel’mintozov. Moscow, 1973.


References in periodicals archive ?
We have chosen the brownish white color derived from thin sliced pieces of the nuts which have a high qualitative content of Arecoline as one of the active ingredients in antihelmintic action of Areca catechu Linn.
The oils of several other Melaleuca spp notably quinquinervia (nerolidol, linalool and 1,8-cineole chemotypes) and ericifolia are also strongly bactericidal(20) and may find uses in the future whereas the oil of Melaleuca cajuputi (cajuput oil) containing 50-70% 1,8 cineol and 30% terpineol is known for its antispasmodic and antihelmintic properties (3).
Mebendazole, albendazole, and antihelmintic drugs are used for chemotherapy.
30,31,44] Albendazole is a broad-spectrum oral antihelmintic drug.