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A drug, such as quinacrine, that prevents or suppresses malaria.
Acting against malaria.



a medicinal preparation for the treatment and prophylaxis of malaria. Antimalarials are classified into several groups according to their selective or predominant effect on various forms of plasmodia. For example, quinacrine hydrochloride, chloroquine, and quinine kill schizonts in the blood and rapidly curtail malarial attacks, while quinocide and primaquine destroy malarial parasites in tissues and prevent future relapses of tertian and quartan malaria. For this reason, drugs of both groups are usually used with the above forms of malaria. Proguanil hydrochloride acts on the erythrocytic and sexual forms of plasmodia; it is especially effective against the pathogen that produces falciparum malaria. Quinocide and primaquine also kill the gamonts of pathogens and, as a result, the infected person remains noninfective for the mosquito. Quinine is usually used in regions where the pathogens that produce falciparum malaria are resistant to chloroquine. The administration of antimalarials, such as chloroquine, to healthy individuals is used in the chemoprophylaxis of malarial foci.

Most antimalarials are obtained synthetically. Quinine, for example, is an alkaloid of a cinchona tree. Antimalarials are also used to treat certain diseases caused by protozoans or helminths; for example, quinacrine hydrochloride is used to treat amebiasis, giardiasis, and leishmaniasis, while pyrimethamine is used to treat toxoplasmosis.


Moshkovskii, Sh. D., ed. Ukazaniia po lecheniiu i khimioprofilaktike maliarii. Moscow, 1972.


References in periodicals archive ?
Sleeping under insecticide-treated mosquito nets, spraying indoors with mosquito sprays, and using artemisinin-based combination therapy (ACTs) among other effective antimalarial medications have been of utmost help in seeing the end of malaria in many countries around the world.
Over the past decade, we have delivered 700 million antimalarial treatments without profit in malaria-endemic countries but more work is needed.
Under this agreement, the three parties will conduct preclinical and clinical development of the oral antimalarial candidate compound SJ733.
In addition, antimalarial valances are distributed among pregnant women and families with children aged under 5.
One of the latter, called BDNF (for brain-derived neurotropic factor), was also increased in the blood of adult human patients with uncomplicated malaria who had participated in a clinical trial and received antimalarial drugs plus rosiglitazone, compared with other trial participants who had only taken antimalarials.
Some important considerations to ensure effective malaria case management include availability and accessibility of antimalarial medicines, training of healthcare workers at all levels of healthcare delivery and dealing with the problem of antimalarial drug resistance.
This is an excellent evaluation of an exciting new series of antimalarial drugs,' says Nick White of the Mahidol University in Bangkok, Thailand, a country where resistance is developing fast to artemisinins, the most potent class of antimalarial drugs now in use.
A new study by scientists at Worcester Polytechnic Institute and the University of Massachusetts has shown that the powdered dried leaves from the Artemisia annua plant may be a far more effective antimalarial treatment than purified artemisinin, delivering 40 times more artemisinin to the blood and reducing the level of parasite infection more completely in mice.
vivax which are resistant to first and second line antimalarials (multidrug resistant or MDR) have motivated the search for new drugs representing new and distinct chemical classes and mechanisms of action than those of the antimalarial drugs currently in use.
BOSTON--The use of adjunctive therapy and a lot of patience may go a long way to improving the response of cutaneous lupus erythematosus to antimalarial agents, according to Dr.
Poor-quality and fake antimalarial drugs are leading to both drug resistance and inadequate treatment that is jeopardizing global efforts to control and eliminate the disease, a recent study found.