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A drug, such as quinacrine, that prevents or suppresses malaria.
Acting against malaria.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a medicinal preparation for the treatment and prophylaxis of malaria. Antimalarials are classified into several groups according to their selective or predominant effect on various forms of plasmodia. For example, quinacrine hydrochloride, chloroquine, and quinine kill schizonts in the blood and rapidly curtail malarial attacks, while quinocide and primaquine destroy malarial parasites in tissues and prevent future relapses of tertian and quartan malaria. For this reason, drugs of both groups are usually used with the above forms of malaria. Proguanil hydrochloride acts on the erythrocytic and sexual forms of plasmodia; it is especially effective against the pathogen that produces falciparum malaria. Quinocide and primaquine also kill the gamonts of pathogens and, as a result, the infected person remains noninfective for the mosquito. Quinine is usually used in regions where the pathogens that produce falciparum malaria are resistant to chloroquine. The administration of antimalarials, such as chloroquine, to healthy individuals is used in the chemoprophylaxis of malarial foci.

Most antimalarials are obtained synthetically. Quinine, for example, is an alkaloid of a cinchona tree. Antimalarials are also used to treat certain diseases caused by protozoans or helminths; for example, quinacrine hydrochloride is used to treat amebiasis, giardiasis, and leishmaniasis, while pyrimethamine is used to treat toxoplasmosis.


Moshkovskii, Sh. D., ed. Ukazaniia po lecheniiu i khimioprofilaktike maliarii. Moscow, 1972.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
vivax which are resistant to first and second line antimalarials (multidrug resistant or MDR) have motivated the search for new drugs representing new and distinct chemical classes and mechanisms of action than those of the antimalarial drugs currently in use.
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We assessed susceptibility to 11 antimalarial drugs on the fresh isolate and after culture adaptation (Table).
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For its part, Novartis recently announced that it will invest more than $100 million in antimalarial RandD over the next five years, to help contain emerging resistant strains of the disease.
Previously, kaempferol isolated from the leaves of Schima wallichii was shown to exert a potent antimalarial activity against chloroquine-resistant P.
The antimalarial drug policy was formulated to promote rational use of antimalarial drugs in order to reduce the development of drug resistance.
Monitoring drug efficacy, safety, quality of antimalarials is ongoing, as is discouraging monotherapy use of these agents.
announced today that it has entered into a new joint research agreement with the Broad Institute, a collaborative research institute which includes researchers from the Massachusetts Institute of Technology and Harvard University to develop a new antimalarial medicine based on antimalarial drug targets the team identified last year.
Isoquine and related amodiaquine analogues: A new generation of improved 4-aminoquinoline antimalarials. J Med Chem.
In a broader way antimalarial drugs are generally categorized into different groups depending on the stage of the plasmodium life cycle on which they act; Quinoline antimalarials, 4-aminoquinoline series, Antifolate Derivatives and DOXP Reductoisomerase Inhibitors For many years, malaria was treated successfully using chloroquine (CQ) and antifolate derivatives.