The folate antimetabolites
segment is projected to be the second highest segment of the global NSCLC therapeutics market.
For caregivers and their patients, the therapeutic area that is at the forefront of attempts to mitigate exposure to cytotoxic drugs is clinical oncology, a field that continues to rely heavily on antineoplastics, a class that includes alkylating agents and antimetabolites
, to treat a wide range of cancers.
Patients who prove resistant to firstline therapy can try antimetabolites
or a few other agents of last resort (see box), although "none of them work wonderfully," Dr.
Its oral bioavailability is unique for most antimetabolites
and gives promise for future therapeutic development.
Although a plethora of platinum-based chemotherapy combinations may be prescribed for the treatment of non small cell lung cancer (NSCLC) the market is currently driven by chemotherapeutic agents such as taxanes and antimetabolites
, and the increasing use of targeted therapies.
The pre-clinical tests are being conducted with various groups of cytostatics (alkylating agents, antimetabolites
, plant alkaloids, etc) with promising results; e.
The key classes of mechanism of action include EGFR inhibitors, VEGF inhibitors, monoclonal antibodies, angiogenesis inhibitors, immunotherapies, antimetabolites
, fluoropyrimidine modulators, tyrosine kinase inhibitors, folate analogs, topoisomerase 1 inhibitors, insulin-like growth factor receptor (IGFR) inhibitors, pathway inhibitors, TRAIL receptor 1 antibodies and apoptosis inducers.
The technique maintains a reasonably high success rate of trabeculectomy and reduces the complications of adjunctive antimetabolites
or aqueous drainage devices.
Perifosine in combination with antimetabolites
induces synergistic effects on cytotoxicity and apoptosis in human colon, multiple myeloma, breast, renal, and liver tumor cell lines," B.
These capital improvements now allow us to provide cGMP contract packaging services for select potent pharmaceutical compounds such as enzymes, antibiotics, antifolates, antimetabolites
and some hormones," said Tony Fenno, Chief Operating Officer.
Nascobal Nasal Spray is also indicated as a supplement for other vitamin B12 deficiencies including: dietary deficiency of vitamin B12 occurring in strict vegetarian diets; malabsorption of vitamin B12 resulting from conditions including HIV infection, AIDS, and Crohn's disease; inadequate secretion of intrinsic factor resulting from lesions that destroy the gastric mucosa, and other conditions associated with gastric atrophy, including multiple sclerosis, HIV infection, AIDS, certain endocrine disorders, iron deficiency, and subtotal gastrectomy; total gastrectomy; competition for vitamin B12 by intestinal parasites or bacteria; and inadequate utilization of vitamin B12 that may occur if antimetabolites
for the vitamin are employed in the treatment of neoplasia.
are forecast to account for the largest proportion of market share through to 2018 14