section]) Conditions include human immunodeficiency virus/acquired immune deficiency syndrome infection, leukemia, lymphoma, generalized malignancy, solid organ transplantation, therapy with alkylating agents, antimetabolites
, radiation, tumor necrosis factor inhibitors, high-dose corticosteroids, being a recipient with hematopoietic stem cell transplant <24 months post-transplant or >24 months but with graft-versus-host disease or disease relapse, or having autoimmune disease with immunodeficiency as a clinical component.
Alkylating agents are utilized in cases showing insufficient treatment response to antimetabolites
or combination therapy.
Other types of antimetabolites
interfere with proteins: L-Canavanine (L-CAV), a non-protein amino acid found in several plants of the family Fabaceae, is a structural homologue of L-arginine (LARG).
Isofol's lead clinical candidate, Modufolin, is predicted to improve the outlook for cancer patients undergoing chemotherapy treatment with a range of antimetabolites
Exclusion criteria included eyes with uveitis, rubeotic eyes, and eyes which have had previous intraocular surgery or in which antimetabolite
supplementation was to be used, the only demonstrable risk factor for failure in our patients was the prior use of topical anti-glaucoma medications and the two groups were selected keeping the factor distributed symmetrically.
Different types of selection systems are available including genes conferring resistance to antibiotics, antimetabolites
, herbicides, hormone biosynthesis and toxic levels of amino acids and their analogs.
Methotrxate and aminopterin are two uncommon antimetabolites
that can induce cranial dysplasia and cleft palate in human.
In our patient, we were concerned that haemolysis due to DDS in the presence of bone marrow depression caused by the antimetabolites
(the levels of which were unavailable at the time), could be catastrophic.
One of a group of chemotherapy drugs known as antimetabolites
, it prevents cells from making DNA and RNA - ribonucleic acid - which causes cells to die.
that interfere with the synthesis of amino and nucleic acids
Other topics of the 66 chapters include topoisomerase inhibitors, antimetabolites
, cytokines, monoclonal antibodies, biophosphonates, anemia, metabolic emergencies, and pain management.
are substances that are chemically very similar to the building blocks of DNA and RNA--purine and pyrimidine.