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Related to Antiphospholipid antibody: Antiphospholipid antibody syndrome
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Primary prevention in antiphospholipid antibody carriers.
Autoantibodies to beta2-glycoprotein I in systemic lupus erythematosus and primary antiphospholipid antibody syndrome: clinical correlations in comparison with other antiphospholipid antibody tests.
Assessing the variation in antiphospholipid antibody (APA) assays: comparison of results from 10 centers.
Another recent trial, the Antiphospholipid Antibody and Stroke Study (APASS), (59) found no difference in recurrence rate of stroke in aPL-positive patients randomized to aspirin versus warfarin.
In patients presenting with thrombocytopenia, diagnosis of ITP is made by exclusion of conditions that may cause thrombocytopenia, which include: drug use (generally heparin, alcohol, quinine/quinidine, sulphonamides), bacterial infections, viral infections (HIV, hepatitis, cytomegalovirus, Epstein-Barr virus), rickettsia infections, mycoplasma infections, lymphoproliferative diseases (chronic lymphocytic leukemia, large granular lymphocytic leukemia, lymphoma), autoimmune diseases (especially systemic lupus erythematosus, antiphospholipid antibody (APA) syndrome), disseminated intravascular coagulopathy, hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, preeclampsia/eclampsia, HELLP syndrome, gestational thrombocytopenia, and hypersplenism.
Mild or moderate disease flares occurred in 6% of women within 20 weeks of gestation, in 5% at 32 weeks, and in 8% during the postpartum period, according to data from the PROMISSE (Predictors of Pregnancy Outcome: Biomarkers in Antiphospholipid Antibody Syndrome and Systemic Lupus Erythematosus) study.
She also has antiphospholipid antibody syndrome with recurrent deep vein thromboses and pulmonary embolisms necessitating a Greenfield filter placement, which has been complicated by venous stasis syndrome.
Bermas has a special interest in the treatment of rheumatic diseases during pregnancy, the antiphospholipid antibody syndrome, and lupus.
This review addresses new clinical issues (revealed at the 2006 Sydney update of the 1999 Sapporo Classification criteria; cardiac, renal, and multiple sclerosis-like disease; catastrophic syndrome), mechanisms of action of antiphospholipid antibody (very likely complement mediated), current therapies (moderate dose warfarin recommended for prophylaxis, aspirin not recommended for primary prophylaxis), and potential new therapies.
The seventh woman lost her fetus during the second trimester because of a very aggressive case of the pro-thrombotic condition known as antiphospholipid antibody syndrome, which boosted her risk for developing DVT during pregnancy, said Dr.
Women with lupus and antiphospholipid antibody syndrome are also at higher risk of fetal loss, arterial and venous thrombosis, renal vasculitis, and preeclampsia.