Antispasmodic

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antispasmodic

[¦an·tē‚spaz′mäd·ik]
(pharmacology)
An agent, such as benzyl benzoate, that relieves convulsions and the pain of muscular spasms.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Antispasmodic

 

one of a group of pharmacological substances with various chemical structures that induce the relaxation of the smooth muscles of, for example, the blood vessels, bronchi, and gastrointestinal, biliary, and urinary tracts.

Antispasmodics may be, according to their mechanism of action, neurotropic or musculotropic. Neurotropic agents include cholinolytics, for example, such m-cholinolytics as atropine, spasmolytin, thiphen, aprophen, and diprophen. Conventionally, they also include sympathomimetics (Adrenalin, ephedrine, Is-adrine [Aleudrin]), which relax the smooth muscles of the bronchi, intestines, and other organs by exciting sympathetic nerves. Musculotropic antispasmodics, including papaverine and drotav-erinum, directly act on the smooth muscles.

Antispasmodics are used to treat many diseases accompanied by the intensified contraction of the smooth muscles, including asthma, renal colic, and spasms of the cerebral blood vessels.

REFERENCES

Kuznetsov, S. G., and S. N. Golikov. Sinteticheskie alropinopodobnye veshchestva. Leningrad, 1962. (Bibliography.)
Wesselius de Casparis, A. “Neurotropic Versus Musculotropic Antispasmodics.” Medicamundi, 1962, vol. 8, no. 5, pp. 92–98. (Bibliography.)

V. V. ZAKUSOV

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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The time interval between admission and 4 cm cervical dilatation and injection of antispasmodic to full cervical dilatation were noted.
Within these two subgroups, further division was done depending upon whether the antispasmodic was given at less than 5 cm cervical dilatation or more than 5 cm cervical dilatation.
Overall, the available data suggest that exposure to an antispasmodic in pregnancy is low risk for embryo, fetal, and newborn harm.
A 2011 Cochrane review of 56 randomized controlled trials (RCTs) with 3725 patients compared bulking agents, antispasmodics, or antidepressants with placebo for treating IBS.
The clinical relevance of the antispasmodic data is limited because the antispasmodics found effective for abdominal pain aren't available in the United States.
Trials included in the review needed to compare fibre, antispasmodics or peppermint oil with a placebo or no treatment.
A total of 35 trials were included in this review: 9 trials compared fibre with either a placebo or no treatment, 19 trials compared antispasmodics with placebo, 4 trials compared peppermint oil with placebo, and 3 trials compared both fibre and antispasmodics with placebo.
About 54 per cent of patients put on to a high bran diet had unimproved symptoms, while 39 per cent treated with antispasmodics had unimproved symptoms after treatment.
Fibre, antispasmodics and peppermint oil were all found to be effective treatments for IBS and none of the treatments had serious adverse effects.
It is an antispasmodic that contains substances that promote GI smooth-muscle relaxation.