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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a medicinal preparation that has a specific effect on the pathogen of tuberculosis. There are two groups of antituberculotics: principal antituberculotics and reserve antituberculotics.

Principal antituberculotics include isoniazid; hydrazide of isonicotinic acid and its derivatives, including Phthivazid, Methazid, saluzid, and Larusan; antibiotics, including streptomycin sulfate and dihydrostreptomycin sulfate; and sodium of para-aminosalicylic acid (PAS), BEPASC (benzacyl), and Pasomycin, which consists of dihydrostreptomycin in combination with PAS.

Reserve antituberculotics are used mainly to act on the mycobacteria of tuberculosis that have become resistant to preparations of the first group. They include antibiotics, for example, kanamycin, phaoromycin, and cycloserine, and such preparations as ethionamide, protionamide, pyrazinamide, ethoxyde, and tibione.

The antituberculotics rifampicin and ethambutol were created in the 1960’s. They are used in chronic forms of tuberculosis that have not responded to prolonged therapy with preparations of the first and second groups and in cases when other antituberculotics are not tolerated.


Shebanov, F. V. Tuberkulez. Moscow, 1969.
Rabukhin, A. E. Khimioterapiia bol’nykh tuberkulezom. Moscow, 1970.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
The principle of treatment of bone and joint tuberculosis in those days before the discovery of antibiotics and antituberculotics consisted in raising the general resistance of the patient hygienic-dietary regime, fresh air therapy, heliotherapy (natural sunshine during the day, artificial light during winter days) (Figure 4), immobilization and a variety of surgical procedures.
Nevertheless, N-benzoyl carbamate derivatives were also identified as potential antituberculotics [6-17].
Based on previous interesting results of similar structures as new potential antituberculotics [12-17], a series of substituted N-arylcarbonyloxypropanol-N-aryloxyethyl-amines was synthesized, and selected physicochemical characteristics were described along with their antimycobacterial activity and cytotoxicity.
Ferriz et al., "New antituberculotics originated from salicylanilides with promising in vitro activity against atypical mycobacterial strains," Bioorganic and Medicinal Chemistry, vol.
Glycoresins have been reported to possess a number of biological activities, such as antibacterial (Pereda-Miranda et al., 2006a), antituberculotic (Barnes et al., 2003), antitumoral (Cao et al., 2005; Leon et al., 2005), purgative (Pereda-Miranda et al., 2006b), antidepressant and anticonvulsant (Miron-Lopez et al., 2007).