apoptosis

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apoptosis

[‚ā·pō′tō·səs]
(cell and molecular biology)
Death of cells triggered by extracellular signals or genetically programmed events, carried out by processes within the cell, and characterized by systemic breakdown of cellular constituents, in particular chromosomal deoxyribonucleic acid; may be involved in normal development and aging, or may serve to eliminate defective or damaged cells. Also known as programmed cell death.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
(27) Maintaining a balance between apoptotic cell death and cell survival has been suggested as a possible survival mechanism of autophagy for germ cells.
LIPO caused less apoptotic cell death on cochlear cells than CDDP at anti-tumoral doses, suggesting a lower toxicity in cochlear cells compared to CDDP.
Furthermore, licofelone induces more late apoptotic/necrotic cells death than early apoptotic cell death in rat hepatoma cells.
Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons.
EGCG Prevented Diabetes-Induced Activation of Testicular Apoptotic Cell Death Signaling via NRF2.
The PI3K/Akt/mTOR signaling pathway is overexpressed or activated in various tumors and may inhibit apoptotic cell death and enhance survival and resistance to chemotherapy of cancer cells [30, 31].
Gemigliptin Attenuated Cisplatin-Induced Apoptotic Cell Death. Apoptotic death of renal tubular cells plays a central role in the pathogenesis of cisplatin-induced nephrotoxicity [2].
Although glucocorticoids have been reported to induce myocardium preservation and protect podocytes against apoptosis [23, 24], glucocorticoids are mainly known to lead to apoptotic cell death and reduce proliferation in a variety of cells, including INS-1 cells [2, 25].
When apoptotic cell death is blocked by pancaspase inhibitors, death signals such as Fas ligand and TNF can trigger necroptosis as an alternative cell death pathway (5).
However, the effects of capsaicin in apoptotic cell death and adipogenesis of BMSCs remain unclear.
In the study we found that treating the cells with 150 [micro]M 6-OHDA induced oxidative stress by initiating a sequence of events that reduce cellular activity leading to apoptotic cell death. We showed that preconditioning PC12 cells by exposing them to a lower concentration of 6-OHDA for a short period before subsequent exposure to a higher concentration resulted in greater cell viability and therefore less cell death.

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